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Allopregnanolone (ALLO), the Pregnancy Neuro-Steroid, is Neuroprotective in Hypoxic-Ischemic Injury of the Immature Brain
This innovation focuses on the potential therapeutic use of Allopregnanolone (ALLO), a natural neurosteroid, to treat hypoxic ischemic (HI) brain injury in premature infants. ALLO, naturally produced in the placenta during brain development, is absent in premature infants, which contributes to the neurological deficits observed in HI cases. The proposed...
Published: 11/21/2025
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Inventor(s): Roberta Brinton, Nahla Zaghloul, Mohamed Ahmed, Akash Gupta, Tian Wang, Fei Yin
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Pediatrics, Technology Classifications > Life Sciences > Therapeutics
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Novel Knockout Model Of ER-Beta in Rat Neurons
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-beta-FloxP-Cre rat that has ER-beta knocked out specifically in neurons.
Background:
Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack...
Published: 11/16/2023
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Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
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Novel Knockout Model Of ER-Alpha in Rat Neurons
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-alpha-FloxP-Cre rat that has ER-alpha knocked out specifically in neurons.
Background:
Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack...
Published: 11/16/2023
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Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
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Novel Forebrain Neuron Specific CreERT2 Rat Model
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors. This specific rat model is forebrain neuron-specific CreERT2 rat model under the CamKII promoter.
Background:
Progress in determining the role of estrogen and its receptors in the brain has been limited by the lack of translatable rat models...
Published: 11/16/2023
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Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
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Novel Conditional Knockout Model Of ER-Beta in Rats
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-beta FloxP rat that can be combined with tissue-specific Cre rats to generate ER-beta knockouts in any tissues expressing the estrogen receptor.
Background:
Progress in determining the role...
Published: 11/16/2023
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Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
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Novel Conditional Knockout Model of ER-Alpha in Rats
This technology is one of a set of five rat models that is focused on the role of estrogen and its receptors within the brain. This specific rat model is an ER-alpha FloxP rat that can be combined with tissue-specific Cre rats to generate ER-alpha knockouts in any tissues expressing the estrogen receptor.
Background:
Progress in determining the role...
Published: 11/16/2023
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Inventor(s): Roberta Brinton, Fei Yin, Tian Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools > Animal Models
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