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Tributyrin to Entain Human Circadian Rhythms and Improve Sleep in Individuals with Medical Disorders that can Increase Gut Permeability or Elevated Levels of Systemic Inflammation

This documents a new method of treatment for sleep improvements. Poor sleep is likely manifested by an underlying irregular circadian rhythm sleep disorder. A patient with a history of leaky gut syndrome and poor sleep took a commercially available oral short-chain fatty acid supplement, tributyrin, and documented improved sleep. This suggests a relationship...

Published: 1/10/2024 | Inventor(s): Sairam Parthasarathy

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Sleep Disorders

Treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) with a Polypeptide

The SARS-CoV-2 virus binds to ACE2, a cell surface protein receptor. The ACE2 binding reduces the ability of ACE2 to break down Angiotensin-II (Ang-II). Ang-II is a potent vasoconstrictor that can increase lung injury and lung edema, increase blood pressure, and can be harmful to organ function at high concentrations. This technology administers a...

Published: 11/16/2023 | Inventor(s): Kathleen Rodgers, Sairam Parthasarathy, Gere deZerega

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases