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Novel, Humanized Transgenic Background Mouse Strain for Neurodegenerative Disease Research
This invention is a transgenic mouse model for the study of neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease. This new model crosses a humanized APOE mouse model with a humanized APP gene, both common implicated genetic factors in Alzheimer’s Disease. The technology also developed a Parkinson’s Disease specific...
Published: 6/25/2024
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Inventor(s): Roberta Brinton, Jean Paul Wiegand, Lisa Campbell
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Neurology
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Novel Mouse Strain for Inflammation and Neurodegeneration
This invention is a transgenic mouse model for the study of multiple sclerosis and rheumatoid arthritis. This new model crosses an HLA transgenic strain with a humanized apolipoprotein E (APOE) mouse model to create a useful tool for studying a wide array of neurodegenerative diseases, specifically the role of T-cell mediated inflammation. This new...
Published: 6/25/2024
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Inventor(s): Roberta Brinton, Kathleen Rodgers, Jean Paul Wiegand, Lisa Campbell
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation
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Rodent/Small Mammal Animal-Free Surgical Training System and Components
This innovation is an animal-free surgical training simulator for use in biomedical research. The system comprises anatomically accurate simulators and step-by-step protocols for training in surgical techniques. The component parts of the simulators can be produced through cost-effective 3D printing, making the system affordable and customizable. These...
Published: 5/7/2024
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Inventor(s): Diego Celdran-Bonafonte
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Software & Information Technology > Education & Training, Technology Classifications > Veterinary Medicine
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Transplantable Murine Cutaneous Squamous Cell Carcinoma Cell Lines
This innovation involves the creation of novel cell lines for studying cutaneous squamous cell carcinoma (cSCC) in mice. These cell lines, derived from UV-induced cSCC tumors in BALB/c mice, recapitulate the mutational signature and driver mutations found in human cSCC. Developing the cell lines from an inbred mouse strain allows for studies involving...
Published: 5/20/2024
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Inventor(s): Karen Hastings, Anngela Adams, Anne Macy
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Healthcare Portfolios > Dermatology, Technology Classifications > Healthcare Portfolios > Oncology
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A Mitochondria-Focused Mouse Model (DRP-1-/- mouse) to Accelerate Gastrointestinal Pathophysiology Research
This invention is a transgenic DRP-1-/- mouse model that will help address the central role of mitochondrial structure-function dynamics in the mammalian intestine. This mouse model harbors an intestine-specific disruption in DRP-1, a key mitochondrial membrane-associated protein, which will be useful in assessing how mitochondrial structure/interaction...
Published: 9/12/2024
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Inventor(s): Virinchipuram Viswanathan, Gayatri Vedantam, Jean Wilson, Jennifer Lising
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models
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A Mitochondria-Focused Mouse Model (OPA-1-/- mouse) to Accelerate Gastrointestinal Pathophysiology Research
The invention is two engineered OPA-1-/- mouse models that will help address the central role of mitochondrial structure-function dynamics in the mammalian intestine – a translationally critical, but extremely underdeveloped, resource. This mouse models harbor an intestine-specific disruption in OPA-1, a key mitochondrial membrane-associated protein,...
Published: 5/20/2024
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Inventor(s): Virinchipuram Viswanathan, Gayatri Vedantam, Jean Wilson, Jennifer Lising
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models
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Human Serum Albumin-Transgenic Mouse
A novel human albumin transgenic mouse model was developed which can be used to establish human protein biomarkers of exposure to hazardous xenobiotics for human risk assessment via animal studies. This can provide a unique in vivo tool for the assessment of risks of toxicity associated with human exposure to environmentally hazardous chemicals and...
Published: 1/10/2024
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Inventor(s): Xinxin Ding
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
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Plasma from Mouse Stroke Model that can be used to detect Neurofilament Light Chain
This invention relates to the intellectual property that consists of a stored archive of hundreds of mouse blood plasma samples that were taken from a laboratory stroke model for mice under various conditions of the mice age and the time past stroke. By evaluating the quantity of neurofilament light (NfL) chain (protein) within the samples they can...
Published: 3/12/2024
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Inventor(s): Kristian Doyle, Jennifer Frye
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Neurology
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Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024
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Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
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A New Mouse Strain (Zip14flox/flox (Slc39a14flox/flox)
University of Arizona researchers have generated a new Zip14flox/flox mouse strain. The strain can be used to generate Zip14 knockout in a tissue-specific manner and is useful to examine tissue-specific function of Zip14.
Applications:
Functional analysis of Zip14
Published: 4/3/2023
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Inventor(s): Ningning Zhao
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models
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