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Dual-Functional Tetrazine Reagents for Bis-Thiol Bioconjugation and Functionalization
This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific bis-thiol targeting.
Background:
Bioconjugates are molecules with altered chemical structures via substrates or reagents that allows for biomolecule...
Published: 2/18/2025
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Inventor(s): Wei Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios, Technology Classifications > Research Tools > Reagents
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Dual Performing Vinyl-tetrazine for Rapid, Selective Bioconjugation and Functionalization of Cysteine Proteins
This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific single-thiol targeting. This novel method possesses an electron withdrawing tetrazine substituted vinyl moiety that exists as a Michael receptor for...
Published: 2/17/2025
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Inventor(s): Wei Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios, Technology Classifications > Research Tools > Reagents
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A Dual-Luciferase Reporter System for Characterization of Small RNA Target Genes in both Mammalian and Insect Cells
MicroRNAs (miRNAs) are regulatory RNA molecules that bind to target messenger RNAs (mRNAs) and affect the stability or translational efficiency of the bound mRNAs. Single or dual-luciferase reporter systems have been successfully used to identify miRNA target genes in mammalian cells, however, they are not sensitive enough to verify miRNA–target...
Published: 5/7/2024
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Inventor(s): Xianchun Li
Keywords(s):
Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Screening assays
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Virus Inducible Switch
This invention describes a novel platform to control expression of specific plant genes with viruses.
Background:
When many plants are challenged with a viral infection, one of the primary defense mechanisms they have evolved is to deploy the use of plant RNA silencing pathways to control gene expression. Likewise, viruses have co-evolved to evade...
Published: 4/3/2023
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Inventor(s): Judith Brown, Cory Keith, Mark Beilstein
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Research Tools > Reagents
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Intracellular Delivery of Small Molecule Reactive Ligands for Bioconjugation
A protected small molecule probe is delivered intracellularly and subsequently releases an aryl diazonium ion for use as a bioconjugation agent or drug delivery agent. This technology enables a novel chemical probe for observing intact biological cells. It builds on previous IP developed by Jewett laboratory for protection, as a class of chemistry enabling...
Published: 10/17/2024
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Inventor(s): John Jewett, Natasha Cornejo, Bismark Amofah, Lindsay Guzman, W Mudiyanselage Anjalee Wijetunge, Indraneel Ghosh, Danielle Johnson, Abigail Shepard
Keywords(s):
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Reagents
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A Method for Characterizing Adeno-Associated Virus Capsids with Thermal Unfolding and Mass Spectrometry
This invention describes modulating the temperature of the solution in an electrospray needle prior to charge-detection mass spectrometry (CD/MS) to enable discrimination between the individual stabilities of multiple forms of viral particles that may be present in an AAV preparation. This increased discrimination provides the operator with a unique...
Published: 3/12/2024
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Inventor(s): Michael Marty, Marius Kostelic
Keywords(s):
Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Research Tools > Reagents, Technology Classifications > Materials > Biomaterials
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Demultiplex Single-Cell Sequencing Data using DNA Barcode Dyes
This technology applies to single cell RNA sequencing data that is created in parallel (multiplexed) to speed the process. Once the multiplexed data exists, it needs to be recombined into one set (demultiplexed) to be useful. This technology is a new demultiplexing technique that uses dyes combined with DNA barcodes, simplifying the demultiplexing process.
Background:
RNA...
Published: 3/5/2025
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Inventor(s): Jared Churko
Keywords(s):
Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools > Screening assays
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Tunable Fluorescent Indolizine Tetracycles
This technology is tunable fluorescent probes that are able to span the colors of the rainbow. The main benefit of this technology is that it can be prepared in only one or two steps; as opposed to the five to seven steps it would normally take. Not only is this technology quicker, but the cost of goods is also more reasonable and compares very favorably...
Published: 11/16/2023
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Inventor(s): Christopher Hulme, Nathan Bedard, Andrew Sennett
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Reagents
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Metal Organic Frameworks for Scintillation Detection of Low Energy Radionuclides
Scintillating metal-organic framework (MOF) particles provide enhanced and robust low-energy β emission sensing in aqueous systems. In addition to being stable and dispersive in aqueous solutions, the scintillating -MOFs are stable and functional in a wide range of organic and aqueous-organic systems and uniquely allow control of excitonic transport...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Chen-Yi Ke, Minhui Han, Brian Zacher
Keywords(s):
Category(s): Technology Classifications > Materials > Nanomaterials, Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Reagents, Technology Classifications > Medical Devices > Diagnostic
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Bioconjugation and Protein Labeling with Photo-Initiated, Bench-Stable, Water-Soluble Triazine Reagents
The invention includes triazines for use as bioconjugates, e.g., for use in protein modification, for use as probes (including but not limited to detectable probes such as fluorescent probes), protein crosslinking, etc. Application of UV light at neutral pH releases diazonium species, which can be used in a wide variety of applications, including protein...
Published: 8/26/2024
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Inventor(s): Garrett Davis, John Jewett
Keywords(s):
Category(s): Technology Classifications > Research Tools > Reagents
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