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A Dual-Luciferase Reporter System for Characterization of Small RNA Target Genes in both Mammalian and Insect Cells

MicroRNAs (miRNAs) are regulatory RNA molecules that bind to target messenger RNAs (mRNAs) and affect the stability or translational efficiency of the bound mRNAs. Single or dual-luciferase reporter systems have been successfully used to identify miRNA target genes in mammalian cells, however, they are not sensitive enough to verify miRNA–target...

Published: 5/7/2024 | Inventor(s): Xianchun Li

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Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Screening assays

Virus Inducible Switch

This invention describes a novel platform to control expression of specific plant genes with viruses. Background: When many plants are challenged with a viral infection, one of the primary defense mechanisms they have evolved is to deploy the use of plant RNA silencing pathways to control gene expression. Likewise, viruses have co-evolved to evade...

Published: 4/3/2023 | Inventor(s): Judith Brown, Cory Keith, Mark Beilstein

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Category(s): Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Research Tools > Reagents

Intracellular Delivery of Small Molecule Reactive Ligands for Bioconjugation

A protected small molecule probe is delivered intracellularly and subsequently releases an aryl diazonium ion for use as a bioconjugation agent or drug delivery agent. This technology enables a novel chemical probe for observing intact biological cells. It builds on previous IP developed by Jewett laboratory for protection, as a class of chemistry enabling...

Published: 10/17/2024 | Inventor(s): John Jewett, Natasha Cornejo, Bismark Amofah, Lindsay Guzman, W Mudiyanselage Anjalee Wijetunge, Indraneel Ghosh, Danielle Johnson, Abigail Shepard

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Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Reagents

A Method for Characterizing Adeno-Associated Virus Capsids with Thermal Unfolding and Mass Spectrometry

This invention describes modulating the temperature of the solution in an electrospray needle prior to charge-detection mass spectrometry (CD/MS) to enable discrimination between the individual stabilities of multiple forms of viral particles that may be present in an AAV preparation. This increased discrimination provides the operator with a unique...

Published: 3/12/2024 | Inventor(s): Michael Marty, Marius Kostelic

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Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines, Technology Classifications > Research Tools > Reagents, Technology Classifications > Materials > Biomaterials

Demultiplex Single-Cell Sequencing Data using DNA Barcode Dyes

This technology applies to single cell RNA sequencing data that is created in parallel (multiplexed) to speed the process. Once the multiplexed data exists, it needs to be recombined into one set (demultiplexed) to be useful. This technology is a new demultiplexing technique that uses dyes combined with DNA barcodes, simplifying the demultiplexing process. Background: RNA...

Published: 4/3/2023 | Inventor(s): Jared Churko

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Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools > Screening assays

Tunable Fluorescent Indolizine Tetracycles

This technology is tunable fluorescent probes that are able to span the colors of the rainbow. The main benefit of this technology is that it can be prepared in only one or two steps; as opposed to the five to seven steps it would normally take. Not only is this technology quicker, but the cost of goods is also more reasonable and compares very favorably...

Published: 11/16/2023 | Inventor(s): Christopher Hulme, Nathan Bedard, Andrew Sennett

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Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Reagents

Metal Organic Frameworks for Scintillation Detection of Low Energy Radionuclides

Scintillating metal-organic framework (MOF) particles provide enhanced and robust low-energy β emission sensing in aqueous systems. In addition to being stable and dispersive in aqueous solutions, the scintillating -MOFs are stable and functional in a wide range of organic and aqueous-organic systems and uniquely allow control of excitonic transport...

Published: 3/12/2024 | Inventor(s): Craig Aspinwall, Chen-Yi Ke, Minhui Han, Brian Zacher

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Category(s): Technology Classifications > Materials > Nanomaterials, Technology Classifications > Materials > Chemicals, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Reagents, Technology Classifications > Medical Devices > Diagnostic

Bioconjugation and Protein Labeling with Photo-Initiated, Bench-Stable, Water-Soluble Triazine Reagents

The invention includes triazines for use as bioconjugates, e.g., for use in protein modification, for use as probes (including but not limited to detectable probes such as fluorescent probes), protein crosslinking, etc. Application of UV light at neutral pH releases diazonium species, which can be used in a wide variety of applications, including protein...

Published: 8/26/2024 | Inventor(s): Garrett Davis, John Jewett

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Category(s): Technology Classifications > Research Tools > Reagents

Shelf-Stable Reagent for Bioconjugation and Protein Labeling

This invention is a new class of amine-reactive, water-stable, small molecules for use as probes, reagents, or bioconjugates. These molecules are lysine-reactive and conjugate quickly without the need for coupling reagents or catalysts. The molecules are simple to synthesize and purify, with high yields. These materials selectively react with lysine...

Published: 6/20/2024 | Inventor(s): John Jewett, Garrett Davis, Holly Sofka

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Category(s): Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Reagents, Technology Classifications > Life Sciences > Diagnostics

Novel Method for Synthesis of Indoles

This invention describes a novel method of generating heterocyclic compounds via a 3+2 annulation. This method does not require expensive reagents and, in some instances, can be completed in a chiral manner. Background: Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents....

Published: 3/12/2024 | Inventor(s): Jon Njardarson, Edon Vitaku

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