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Engineering of piRNA Generating Synthetic RNAs for Greater Stability and Subcellular Targeting
This invention is for a novel bioinsecticide for use in combatting Bemisia tabaci B mitotype NAF-ME cryptic species, the whitefly pest. This new method utilizes piRNA gene splicing techniques to incite lethal phenotypes into the target with increased targeting and specificity for use in other mechanisms.
Background:
RNAi technology falls under the...
Published: 11/4/2024
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Inventor(s): Judith Brown
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Agriculture & Horticulture > Entomology, Technology Classifications > Life Sciences > RNAi/siRNA
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Virus Inducible Switch
This invention describes a novel platform to control expression of specific plant genes with viruses.
Background:
When many plants are challenged with a viral infection, one of the primary defense mechanisms they have evolved is to deploy the use of plant RNA silencing pathways to control gene expression. Likewise, viruses have co-evolved to evade...
Published: 4/3/2023
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Inventor(s): Judith Brown, Cory Keith, Mark Beilstein
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Research Tools > Reagents
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An Alternative Mode of RNA Interference Triggered through Feeding Synthetic RNAs that are Processed into piRNAs
This invention describes a new method of the widely-used RNA interference technique with potential clinical and research applications.
Background:
RNA interference is a commonly used method to knockdown or “silence” genes. This is typically done using small interfering RNA (siRNA) probes designed with specificity to bind and tag certain...
Published: 5/22/2023
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Inventor(s): Judith Brown, Mosharrof Hossain Mondal, Jorge Rafael Paredes Montero, Alex Flynt
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Therapeutics
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Transgenic Resistance to Cotton Leaf Curl Disease in Cotton
This invention utilizes RNA interference techniques to produce a transgenic cotton strain that is resistant to cotton leaf curl disease (CLCuD). These transgenic cotton plants do not produce the characteristic curling of the leaves and do not accumulate the virus. Furthermore, it produces resistance against multiple forms of the virus. This invention...
Published: 4/3/2023
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Inventor(s): Judith Brown, Muhammad Zia-Ur-Rehman
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Agriculture & Horticulture > Plant Pathogens
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Infectious Begomovirus Clones
Infectious viral clones in the form of plasmid vectors are used in experimental inoculation of plants to identify resistant varieties. The varieties listed below may be purchased from the University of Arizona. List of additional varieties and references for all viruses are available upon request.
Partial list of available varieties:
Bean calico...
Published: 4/3/2023
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Inventor(s): Judith Brown
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Agriculture & Horticulture > Crop Improvement
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