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A Flexible, Scalable Platform Technology to Augment Antibiotic Efficacy
This invention relates to a novel, safe, and efficacious approach to reduce antibiotic concentrations required to kill pathogenic bacteria. The product thus augments antibiotic efficacy, including against bacteria that are clinically resistant.
Background:
One of the biggest risks to global public health is antibiotic resistance. Through processes...
Published: 12/1/2025
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan, Arun Sharma, David Stewart
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics
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Novel Mechanism-Based Therapy for Aortic Stiffening and Related Cardiovascular and Cerebrovascular Disorders
This invention involves a novel mechanism-based therapy by using a small molecule compound to reduce aging and hypertensive aortic stiffening, subsequently improve blood pressure (BP) control in resistant hypertension patients and prevent or reverse pathologies of vascular cognitive impairment and dementia (VCID) and Alzheimer’s Disease (AD)....
Published: 11/24/2025
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Inventor(s): Hongyu Qiu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Repurposing the FDA-Approved Antibody to Treat Aortic Stiffening and Resistant Hypertension
This innovation repurposes an FDA-approved antibody to treat and prevent aortic stiffening and resistant hypertension (RH). This mechanism-based therapeutic, inhibits receptor mediated inflammatory and pro-stiffness signaling to reduce aortic stiffness and improve blood pressure control, ultimately breaking the root cycle of hypertension.
Background:...
Published: 11/24/2025
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Inventor(s): Hongyu Qiu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Therapeutics
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Anti-Cancer Peptide Reverses Macrophage Polarity associated with Tumor Growth and Metastasis
This invention is a new anti-cancer peptide for treatment of Triple-Negative Breast Cancer. The new peptide focuses on blocking of Epidermal Growth Factor Receptor (EGFR), which allows for increased M1 macrophage polarity and decreased M2 macrophage polarity. M1 polarized macrophages are associated with tumor regression and an active anti-cancer immune...
Published: 10/24/2025
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Inventor(s): Joyce Schroeder, Ryan Hecksel
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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A Precision Anti-Infective for Enterococcus sp Eradication as well as Selective Decontamination
This innovation is a water-soluble nanocarrier that can precisely and quickly eradicate the healthcare-associated pathogen enterococci. The carrier can complex with oligonucleotides that can bind to bacterial mRNA, preventing translation and inhibiting bacterial functions of enterococci. It is also non-toxic to both human tissue and bacteria and may...
Published: 10/20/2025
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan, Arun Sharma, David Stewart
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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The Use of Cold Plasma to Facilitate CRISPR
This technology is a compact, automated cold plasma generator engineered to enable safe and efficient delivery of CRISPR-Cas9 into cells without chemical reagents. Through the use of cold plasma, cell membranes are transiently permeabilized, creating a controlled pathway for the entry of gene-editing components. This approach directly addresses critical...
Published: 10/9/2025
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Inventor(s): Sara Sheikhlary
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Therapeutics
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Pioneering Cell-Based Solutions for Vascular Aging
This invention is a mechanism-based cell therapy for treating aortic stiffening, particularly in cases of old hypertension patients that do not respond to current treatments. It is also intended to help prevent cardiovascular disease and promote healthy aging in older populations.
Background:
Aortic stiffening is a critical age-related risk factor...
Published: 9/15/2025
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Inventor(s): Hongyu Qiu, Liwu Li
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
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CD64+ AND CD14+ Cell Replacement Therapy for Wound Healing
This technology is a cell-based therapy involving an administered dose of cells expressing both CD14+ and CD64+ ligands. It is designed to promote healing in diabetic patients, with potential to reduce inflammation and support tissue regeneration. The cells can be observed in tissue, blood, and bone marrow, allowing for broader variety in addressing...
Published: 10/14/2025
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Inventor(s): Geoffrey Gurtner, Kellen Chen, Katharina Berryman, Maria Gracia Mora Pinos
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Modifying the Gastric Tumor Microenvironment with Tadalafil
This technology leverages phosphodiesterase 5 (PDE5) inhibitors—such as tadalafil and sildenafil—in combination with the standard of care to treat gastric adenocarcinomas (GAC). The use of PDE5 inhibitors has the potential to enhance immune response and treatment outcomes with a well-established safety profile.
Background:
Gastric adenocarcinoma...
Published: 9/2/2025
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Inventor(s): Juanita Merchant
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Enzyme Replacement Therapy in Niemann-Pick Disease
University of Arizona researchers have developed an acid sphingomyelinas knockout (aSMaseKO) mouse model as a proof-of-concept for using the mutant enzyme in enzyme replacement studies for Niemann-Pick disease (NPD). NPD is a rare, inherited disease that affects the body's ability to metabolize fat within cells. The inventors suggest that a mutant...
Published: 10/26/2025
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Inventor(s): Ashley Snider, Yusuf Hannun, Russel Jenkins, Benjamin Newcomb
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics
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