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Inhibition of Exosome Secretion in Triple Negative Breast Cancer
This invention is a new anti-cancer peptide for treatment of Triple-Negative Breast Cancer (TNBC). This new peptide-based therapeutic focuses on blocking of Epidermal Growth Factor Receptor (EGFR) and SNX1. In addition, this peptide blocks the secretion of harmful exosomes that further cancer cell metastasis and modulate the immune environment.
Background:...
Published: 11/14/2024
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Inventor(s): Joyce Schroeder, Ryan Hecksel, Abigail Camenisch, Delina Denogean, Josh Lederman
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Therapeutics
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C41 Analogs
This invention relates generally to neurodegenerative diseases and conditions, such as Alzheimer’s Disease, characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative...
Published: 9/24/2024
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Inventor(s): Wei Wang, Rui Chang, Vijayan Ramachandran, Patrick Ronaldson
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biologics
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Off-Label Use of an Anti-Hypertensive to Treat Epilepsy
University of Arizona researchers have found the angiotensin II receptor blocker, Candesartan, to effectively reduce epileptic activity.
Background:
As the most prevalent neurological disease, epilepsy is estimated to affect around 50 million people worldwide. In the United States, it is estimated that around 470,000 children and 3 million adults...
Published: 11/14/2024
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Inventor(s): Michael Hammer, Erfan Bahramnejad
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics
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Discovery of Novel Wnt Inhibitors and Uses Thereof
Canonical WNT (Wingless/integrase 1) signaling is an important developmental pathway that has attracted increased attention for anti-cancer drug discovery. Researchers at the University of Arizona are investigating utility for the compounds herein for the treatment of colorectal cancer as well as potential disease modifying agents for the treatment...
Published: 11/14/2024
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Inventor(s): Christopher Hulme, Sammantha Rokey, Yeng Jeng Shaw, Curtis Thorne, Timothy Chavez, Carly Cabel, Nathan Bedard, Sourav Banerjee
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios
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Synthesis of Novel Au(II) Dimers and Investigation of their Potential for Applications in Cancer Treatment
This invention is a method of synthesis of novel Au(II) dimer with pyridine dipyrrolinone (H2PYDP) ligands which demonstrate antiproliferative activity in ovarian cancers. This compound operates with a different mechanism than similar existing drugs allowing for novel combinational drug therapies to be created and tested.
Background:
It is estimated...
Published: 7/8/2024
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Inventor(s): Elisa Tomat, Iva Habensus, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health
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Container Therapeutics at Point of Care
This technology is an innovative method and system for streamlining the production of therapeutic delivery systems. Central to this innovation is the integration of various stages of production, from raw material collection to final product delivery, within a mobile infrastructure. A key embodiment involves the utilization of a container-like structure...
Published: 6/24/2024
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Inventor(s): Frederic Zenhausern
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
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CC16-Derived Analogs for the Treatment of Inflammatory and Obstructive Lung Diseases
This innovation relates to analogs/mimetics of CC16 also known as Urinary protein 1 (UPI), or Clara cell protein, or club cell protein. This protein is targeted for the treatment of cancer, chronic obstructive pulmonary disease, asthma, cystic fibrosis and any other diseases that CC16 may have activity in. The inventors have discovered a novel site...
Published: 6/10/2024
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Inventor(s): Julie Ledford, Josef Vagner, Stefano Guerra, Michael Johnson
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary
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Applications of Deuterated Aldehydes and Isonitriles
This innovation is a novel method of synthesizing calcium channel blockers, with applications to extend the half-life of heart disease medications. This can be used as building blocks to create new pharmaceuticals or potentially used to expand the lifespan of current medications. It has applications to site specific calcium-channel blocking that can...
Published: 6/7/2024
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Inventor(s): Christopher Hulme, Wei Wang, Kevin Schofield, Yueteng Zhang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Compositions for Treating and Preventing Lung Disease
This invention is a novel pharmaceutical composition for supplemental expression of a protein for the treatment of asthma and other pulmonary diseases. This method utilizes a surfactant protein, delivered via aerosolization to offer a more effective treatment option.
Background:
Asthma medicines of the 1940’s and 1950’s consisted of epinephrine...
Published: 11/20/2024
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Inventor(s): Julie Ledford, Monica Kraft, Josef Vagner
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Coronavirus Therapeutics
This technology introduces a potent covalent enzyme inhibitor designed specifically for targeting the cysteine protease, PLpro, a key player in the replication process of SARS coronaviruses like SARS-CoV-2 and MERS. Unlike traditional small molecule inhibitors, this inhibitor offers unparalleled efficacy and specificity, making it a promising candidate...
Published: 6/5/2024
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Inventor(s): Rui Xiong, Gregory Thatcher, Divakar Indukuri, Kiira Ratia, Li jun Rong
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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