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The Use of Cold Plasma to Facilitate CRISPR
This technology is a compact, automated cold plasma generator engineered to enable safe and efficient delivery of CRISPR-Cas9 into cells without chemical reagents. Through the use of cold plasma, cell membranes are transiently permeabilized, creating a controlled pathway for the entry of gene-editing components. This approach directly addresses critical...
Published: 10/9/2025
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Inventor(s): Sara Sheikhlary
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Therapeutics
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Pioneering Cell-Based Solutions for Vascular Aging
This invention is a mechanism-based cell therapy for treating aortic stiffening, particularly in cases of old hypertension patients that do not respond to current treatments. It is also intended to help prevent cardiovascular disease and promote healthy aging in older populations.
Background:
Aortic stiffening is a critical age-related risk factor...
Published: 9/15/2025
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Inventor(s): Hongyu Qiu, Liwu Li
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
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CD64+ AND CD14+ Cell Replacement Therapy for Wound Healing
This technology is a cell-based therapy involving an administered dose of cells expressing both CD14+ and CD64+ ligands. It is designed to promote healing in diabetic patients, with potential to reduce inflammation and support tissue regeneration. The cells can be observed in tissue, blood, and bone marrow, allowing for broader variety in addressing...
Published: 9/15/2025
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Inventor(s): Geoffrey Gurtner, Kellen Chen, Katharina Berryman, Maria Gracia Mora Pinos
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Modifying the Gastric Tumor Microenvironment with Tadalafil
This technology leverages phosphodiesterase 5 (PDE5) inhibitors—such as tadalafil and sildenafil—in combination with the standard of care to treat gastric adenocarcinomas (GAC). The use of PDE5 inhibitors has the potential to enhance immune response and treatment outcomes with a well-established safety profile.
Background:
Gastric adenocarcinoma...
Published: 9/2/2025
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Inventor(s): Juanita Merchant
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Enzyme Replacement Therapy in Niemann-Pick Disease
The inventors have developed an aSMaseKO mouse model that can be utilized as a proof-of-concept for using the mutant enzyme in enzyme replacement studies in patients with Niemann-Pick disease (NPD). NPD is a rare, inherited disease that affects the body's ability to metabolize fat (cholesterol and lipids) within cells. The inventors suggest that...
Published: 8/14/2025
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Inventor(s): Ashley Snider, Yusuf Hannun, Russel Jenkins, Benjamin Newcomb
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics
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Preparation of Apomorphine and its Analogs for Neurodegenerative Disease Applications
This invention involves methods of apomorphine synthesis from different starting blocks to facilitate more robust drug development campaigns by enabling chemical substitutions at unexplored locations. It includes total synthesis of apomorphine from readily available fragments and whose synthetic design approach centers around being maximally amenable...
Published: 8/11/2025
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Inventor(s): Jon Njardarson, Nicholas Lauta
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools > Reagents, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines
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Barettin Analogs
This invention features a novel barettin analogs, which are designed for the treatment of tuberculosis (TB) and chronic pain. Barettin, a naturally derived marine compound, has shown promising biological activity, and these synthetic analogs are optimized to enhance therapeutic effects while minimizing potential side effects. The innovation aims to...
Published: 6/30/2025
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Inventor(s): Christopher Cartmell, Michael Okine, John Streicher, Caleb Seekins
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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Spinal Cord Paddle to Induce Local Hypothermia
This technology is a therapeutic device that provides targeted hypothermia via a paddle to injured spinal cord patients. The system is designed to provide and maintain subfreezing temperatures for 4-5 hours, followed by controlled rewarming over a 20-hour period. The device is manually adjusted to maintain the target cooling profile, and real-time temperature...
Published: 6/23/2025
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Inventor(s): Darya Pershina, Anna Fravel, Janna Said, Amir Sobhan Haghiri, Makena Marie Verdugo, Jesus Zazueta
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Musculoskeletal Disorders, Orthopedics/Bone, Technology Classifications > Healthcare Portfolios > Physical Medicine & Rehabilitation, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Medical Devices > Therapeutic
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Allopregnanolone (ALLO), the Pregnancy Neuro-Steroid, is Neuroprotective in Hypoxic-Ischemic Injury of the Immature Brain
This innovation focuses on the potential therapeutic use of Allopregnanolone (ALLO), a natural neurosteroid, to treat hypoxic ischemic (HI) brain injury in premature infants. ALLO, naturally produced in the placenta during brain development, is absent in premature infants, which contributes to the neurological deficits observed in HI cases. The proposed...
Published: 4/2/2025
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Inventor(s): Roberta Brinton, Nahla Zaghloul
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Pediatrics, Technology Classifications > Life Sciences > Therapeutics
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Expanded use of a Pill Containing Alpha-Galactosidase for Galactose-Alpha-1,3-Galactose Degradation to Treat Alpha-Gal Syndrome Patients
This innovation expands the use of an existing pill originally designed to aid in digesting soy products to help individuals with Alpha-Gal Syndrome (AGS), commonly known as red meat allergy. AGS is triggered by consuming products containing galactose-alpha-1,3-galactose (aGal), which is found in red meat, dairy, gelatin, and collagen-based products....
Published: 3/24/2025
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Inventor(s): Lucia Maldonado Ruiz, Yoonseong Park
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Food Science & Nutrition, Technology Classifications > Life Sciences > Therapeutics
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