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This technology introduces a potent covalent enzyme inhibitor designed specifically for targeting the cysteine protease, PLpro, a key player in the replication process of SARS coronaviruses like SARS-CoV-2 and MERS. Unlike traditional small molecule inhibitors, this inhibitor offers unparalleled efficacy and specificity, making it a promising candidate...

Published: 6/5/2024 | Inventor(s): Rui Xiong, Gregory Thatcher, Divakar Indukuri, Kiira Ratia, Li jun Rong

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

Allosteric NAMPT Activators for Metabolic and Neurological Disorders

This invention relates to a novel method of increasing the catalytic activity of the enzyme, nicotinamide phosphoribosyltransferase (NAMPT), which in turn increases the production of nicotinamide mononucleotide (NMN) that is converted to nicotinamide adenine dinucleotide (NAD). This process to increase supply of NAD in the body is accomplished using...

Published: 11/16/2023 | Inventor(s): Gregory Thatcher, Zhengnan Shen, Rui Xiong, Kiira Ratia, Yangfeng Li

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences