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Secretory Acid Sphingomyelinase Activity as a Diagnostic Marker in Colorectal Cancer

This invention utilizes the activity of secretory acid sphingomyelinase (S-SMase) in patient serum as a biomarker for the early or enhanced detection of colorectal neoplasia, including colorectal cancer (CRC). Background: Colorectal cancer (CRC) is one of the most common cancers worldwide, ranking third in incidence and second in cancer-related deaths...

Published: 9/22/2025 | Inventor(s): Ashley Snider, Nathan Ellis, Justin Snider, Peter Lance

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Diagnostics

Enzyme Replacement Therapy in Niemann-Pick Disease

The inventors have developed an aSMaseKO mouse model that can be utilized as a proof-of-concept for using the mutant enzyme in enzyme replacement studies in patients with Niemann-Pick disease (NPD). NPD is a rare, inherited disease that affects the body's ability to metabolize fat (cholesterol and lipids) within cells. The inventors suggest that...

Published: 8/14/2025 | Inventor(s): Ashley Snider, Yusuf Hannun, Russel Jenkins, Benjamin Newcomb

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Category(s): Technology Classifications > Life Sciences > Therapeutics