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CRISPR-Cas13-Based Isothermal Assay for Multiplex Detection of Circulating MicroRNAs from Small-Volume Blood Samples
This invention relates to the field of molecular diagnostics and nucleic acid detection. In particular, it concerns an isothermal assay platform for the multiplex detection of circulating microRNAs (miRNAs) in small-volume blood samples. The platform is useful for early detection, screening, or monitoring of diseases such as cancer and other conditions.
Background:...
Published: 2/16/2026
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Inventor(s): Ravi Goyal
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease
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Isolation and Separation of Angiotensin I and II from Human Serum Using a New Chromatographic Matrix that Excludes High Molecular Weight Proteins
This innovation introduces a novel chromatographic matrix that effectively isolates and separates angiotensin I and II, key biomarkers involved in blood pressure regulation, from human serum. The system uses a hybrid combination matrix that selectively removes small molecular weight polypeptides while excluding large serum proteins. By integrating chelating...
Published: 1/6/2026
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Inventor(s): Roberto Guzman, David Mier-Salazar, Daniel Alejandro Diaz
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease, Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Medical Devices > Diagnostic
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Analytical Technology for the Isolation of 3-Nitrotyrosine as a Biomarker from Urine to Assess Depression and Acute Kidney Injury
This invention uses a novel separation technique to isolate specific biomarkers from urine, as a measure to detect and monitor depression and acute kidney injury (AKI). The system employs a hybrid chromatographic matrix that rejects biomolecules of specific sizes and allows only the desired small compounds, such as 3-nitrotyrosine (which has been linked...
Published: 1/6/2026
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Inventor(s): Roberto Guzman, David Mier-Salazar
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Nephrology/Renal, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Medical Devices > Diagnostic
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SAGE: A Low-Cost, High-Throughput Disease Agnostic Microfluidic Discovery Engine
This technology relates to a low-cost, high throughput microfluidic platform device which can help identify therapeutic compounds from a known agent, such as tuberculosis. Through a three-chip process, the invention can encapsulate, cultivate, screen and sort bacteria from a host of environmental microbes for bioactive natural products. The platform...
Published: 12/8/2025
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Inventor(s): Christopher Cartmell, John Streicher
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Research Tools
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Isolation of Protein Biomarkers from Saliva as a Technology to Assess and Monitor Cardiac Infarction
This technology introduces a novel separation method designed to isolate small protein biomarkers directly from saliva, enabling a rapid and non-invasive diagnostic approach for cardiac infarction. The system employs a hybrid chromatographic matrix that selectively rejects large proteins while allowing smaller biomarkers to interact with affinity sites...
Published: 11/24/2025
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Inventor(s): Roberto Guzman, David Mier-Salazar, Christopher Rodriguez
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic
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Real-Time Hemoglobin-Based Blood Loss Estimation System Using Disposable Reagent Cartridges
This invention relates to a novel, real-time blood loss quantification device for use in surgical and obstetric settings. This system estimates blood volume absorbed by surgical gauze or sponges by extracting hemoglobin into a fixed-volume reagent, then quantifying absorbance using optical detection methods. This solution improves accuracy over gravimetric...
Published: 10/20/2025
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Inventor(s): Ravi Goyal
Keywords(s):
Category(s): Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease, Technology Classifications > Healthcare Portfolios > Emergency Medicine, Technology Classifications > Healthcare Portfolios > Reproductive Health: Obstetrics & Gynecology
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Spectrometer-Free Biosensing Using Photonic Diffractive Computing for Direct Optical Readout
This invention introduces a photonic diffractive computing biosensing system that converts analyte-induced spectral changes directly into distinct spatial intensity patterns, enabling classification or concentration measurement without spectral reconstruction. An element in the system produces a resonance shift after detection, which produces a diffraction...
Published: 12/23/2025
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Inventor(s): Mohamed ElKabbash
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Mass Spectrometry, Technology Classifications > Engineering & Physical Sciences > Photonics, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Sensors & Controls > Biologic
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SHIP: A Smart Non Wearable Device to Track Sleep Hygiene and Diagnose Sleep Disorders
The Sleep Hygiene Innovation Pillow (SHIP) is a non-wearable smart system that transforms a traditional pillow into a health monitoring device. SHIP uses sensors to continuously record head movement patterns during sleep, then processes that data through proprietary signal analysis and a machine learning algorithm that distinguishes between normal physiological...
Published: 9/19/2025
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Inventor(s): Sumit Agarwal, Joyce Iannotti, Pooja Rangan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Sleep Disorders, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology > Mobile Application
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Lateral Flow Assay for sFlt1/PlGF Biomarker Detection in Preeclampsia Diagnosis
This technology is for a novel lateral flow strip (LFS) diagnostic assay for early diagnosis of preeclampsia in prenatal care. This point-of-care test aims to measure the soluble fms-like tyrosine kinase-1 (sFlt1) to placental growth factor (PlGF) ratio within the blood in order to determine preeclampsia risks in a timely manner. A mobile app assists...
Published: 8/13/2025
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Inventor(s): Ravi Goyal
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Reproductive Health: Obstetrics & Gynecology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Healthcare Portfolios > Urology
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Δ-cps1 Mutant as a Target to Detect Coccidioides Immunity
This technology is a diagnostic platform that utilizes Flow Link Immunosorbent Assay (FLISA) and Δ-cps1, a live attenuated strain of Coccidioides posadasii, to detect if an individual (including animals) has mounted a response to coccidioidomycosis either from infection or vaccination. Δ-cps1 can be used as a stimulus to detect cellular...
Published: 10/10/2025
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Inventor(s): Daniel Powell, Lisa Shubitz, Marc Orbach, John Galgiani
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Veterinary Medicine > Diagnostics, Technology Classifications > Medical Devices > Diagnostic
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