A Sensitive 3D Lateral Flow Device

Case ID:
UA25-066
Invention:

This technology is a lateral flow device (LFD), that enables the processing of significantly larger sample volumes while maintaining rapid detection times. By reimagining the structure of the nitrocellulose (NC) membrane—the heart of LFDs—in 3-dimensional structures, this invention incorporates shorter, thinner, and more focused flow sensing pathways, which boost sensitivity and precision. These innovative features pave the way for faster and more accurate diagnostic results, particularly in critical fields such as healthcare, agriculture, and environmental monitoring.  

Background: 
Traditional LFDs face limitations due to their reliance on long NC membranes, which process small sample volumes and often struggle with low sensitivity. These issues are compounded by slow flow rates, making it challenging to achieve rapid and accurate detection of trace substances. While current solutions aim to enhance sensitivity through chemical modifications or advanced reagents, they fail to address the fundamental design constraints of the LFD itself. This invention overcomes these challenges by focusing on the structural optimization of the NC membrane, offering a transformative improvement over existing technology.

Applications:

  • Biomedical diagnostics 
  • Agricultural monitoring 
  • Food safety 
  • Environmental sensing 


Advantages:

  • Processes larger sample volumes than traditional LFDs
  • Higher sensitivity for more accurate results
  • Faster detection
  • Compact design
  • Enhanced precision for more reliable analyte detection
  • Versatile, applicable across multiple fields
Patent Information:
Contact For More Information:
Garrett Edmunds
Licensing Manager, UAHS-TLA
The University of Arizona
gedmunds@arizona.edu
Lead Inventor(s):
Jian Gu
Frederic Zenhausern
Keywords: