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DHODH Inhibitors
This technology includes novel compounds that selectively inhibit fungal dihydroorotate dehydrogenase (DHODH), an essential enzyme in pyrimidine biosynthesis. These inhibitors are active against a range of fungal pathogens, including Cryptococcus neoformans and Candida auris, while sparing the human version of the enzyme. This selectivity reduces the...
Published: 8/18/2025
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Inventor(s): Hongmin Li, Anil Tharappel, Zhong Li
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Small Molecules
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Preparation of Apomorphine and its Analogs for Neurodegenerative Disease Applications
This invention involves methods of apomorphine synthesis from different starting blocks to facilitate more robust drug development campaigns by enabling chemical substitutions at unexplored locations. It includes total synthesis of apomorphine from readily available fragments and whose synthetic design approach centers around being maximally amenable...
Published: 8/11/2025
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Inventor(s): Jon Njardarson, Nicholas Lauta
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools > Reagents, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines
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Barettin Analogs
This invention features a novel barettin analogs, which are designed for the treatment of tuberculosis (TB) and chronic pain. Barettin, a naturally derived marine compound, has shown promising biological activity, and these synthetic analogs are optimized to enhance therapeutic effects while minimizing potential side effects. The innovation aims to...
Published: 6/30/2025
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Inventor(s): Christopher Cartmell, Michael Okine, John Streicher, Caleb Seekins
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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New Therapeutic Strategy for Pancreatic Cancer with Wnt Inhibitors from Phenoxazine Derivatives
This invention is for a novel small molecule therapy for the treatment of Pancreatic ductal adenocarcinoma (PDAC). This new set of compounds contain inhibitors that have shown successfully slowed tumor progression by reducing expression of two major tumor-causing mutated oncoproteins in mouse models.
Background:
Pancreatic ductal adenocarcinoma (PDAC)...
Published: 3/24/2025
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Inventor(s): Daekyu Sun
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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Monofunctional MDM2 Degraders for Disease Treatment
This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors.
Background:
The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...
Published: 3/24/2025
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Inventor(s): Wei Wang, Jennifer Carew, Steffan Nawrocki, Mengyang Chang, Fangchao Bi
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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Kinase Suppressors for Cancer Therapy
Mixed Lineage Kinase 3 (MLK3) has been identified as a promising target for cancer therapy, particularly for addressing aggressive cancers such as triple-negative breast cancer (TNBC). TNBC is a challenging cancer type with limited treatment options and disproportionately affects certain populations. This innovative technology focuses on a series of...
Published: 3/17/2025
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Inventor(s): Gregory Thatcher, Ganga Reddy Velma, Rui Xiong
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Small Molecules
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Dual-Functional Tetrazine Reagents for Bis-Thiol Bioconjugation and Functionalization
This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific bis-thiol targeting.
Background:
Bioconjugates are molecules with altered chemical structures via substrates or reagents that allows for biomolecule...
Published: 2/18/2025
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Inventor(s): Wei Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios, Technology Classifications > Research Tools > Reagents
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Dual Performing Vinyl-tetrazine for Rapid, Selective Bioconjugation and Functionalization of Cysteine Proteins
This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific single-thiol targeting. This novel method possesses an electron withdrawing tetrazine substituted vinyl moiety that exists as a Michael receptor for...
Published: 2/17/2025
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Inventor(s): Wei Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios, Technology Classifications > Research Tools > Reagents
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Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C-H Bonds via H/D Exchange with D2O
This technology presents an organophotocatalytic method for selective deuteration of metabolically labile α-positions in amides, amines, and secondary alcohols. This approach achieves high regioselectivity and deuterium incorporation by masking secondary amines as carbamates and employing a photoredox-HAT (hydrogen atom transfer) process. This...
Published: 1/21/2025
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Inventor(s): Wei Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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A Novel Chemical Entity, Mary1, for the Treatment Mitochondrial Dysfunction, Vascular Injury, Kidney Diseases, and Organ Aging
This invention is a novel compound that can be used as a treatment for Acute Kidney Injury (AKI). This new method utilizes a small molecule agonist, capable of increasing mitochondrial biogenesis, which helps restore mitochondrial homeostasis and improves renal function and recovery. The compound showed beneficial effect in mouse model experiments.
Background:...
Published: 8/5/2024
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Inventor(s): Rick Schnellmann, Paul Victor Santiago Raj
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Nephrology/Renal, Technology Classifications > Life Sciences > Small Molecules
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