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New Therapeutic Strategy for Pancreatic Cancer with Wnt Inhibitors from Phenoxazine Derivatives

This invention is for a novel small molecule therapy for the treatment of Pancreatic ductal adenocarcinoma (PDAC). This new set of compounds contain inhibitors that have shown successfully slowed tumor progression by reducing expression of two major tumor-causing mutated oncoproteins in mouse models. Background: Pancreatic ductal adenocarcinoma (PDAC)...

Published: 3/24/2025 | Inventor(s): Daekyu Sun

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules

Repurposing of a Known Drug for Treatment of the Novel Coronavirus SARS-CoV-2 (COVID-19)

This invention introduces a novel use for an existing pharmaceutical. This new use will allow the existing drug to be used to treat COVID-19. This known drug was recently found to be effective in interacting with COVID-19 genes. This interaction has led to antiviral activity against COVID-19 in in vitro cell cultures. Background: The coronavirus pandemic...

Published: 7/26/2024 | Inventor(s): Daekyu Sun

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics

Combination Treatment for Cancer Involving CX-3543 and a PARP Inhibitor

Researchers at the University of Arizona have discovered that the addition of benzamide to HeLA cells prior to treatment with CX-3543 results in an increase in nucleolin bound to the NHE III1 element of the c-Myc promoter. Further analysis of the data indicated that there is a significant increase in the induction of apoptosis over that of CX-3543 alone....

Published: 11/16/2023 | Inventor(s): Laurence Hurley, Daekyu Sun, Mary Guzman, Tiffanie Powell Bialis, Veronica Gonzalez-Pena

Keywords(s):

Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules