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C41 Analogs
This invention generally relates to neurodegenerative diseases and conditions, such as Alzheimer’s disease, characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative...
Published: 12/5/2024
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Inventor(s): Wei Wang, Rui Chang, Vijayan Ramachandran, Patrick Ronaldson
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biologics
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Cosmetic Hyaluronic Acid Binding Peptides
The invention focuses on developing a novel gel technology aimed at rejuvenating aging skin by targeting hyaluronic acid (HA) receptors. These receptors, crucial for skin hydration and elasticity, decline with age, contributing to skin aging. The gel incorporates peptides designed to mimic HA receptors, enhancing their binding to HA molecules and effectively...
Published: 8/5/2024
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Inventor(s): Kyle Koss, Terrance Sereda
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Dermatology, Technology Classifications > Life Sciences > Biologics
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Time Resolved Fluorescence based HTS to Detect Structural Changes in cTnI
This innovation involves the development of a probe that attaches to a specific protein called cardiac troponin I (cTnI), which is involved in muscle contraction of the heart. This probe, created through genetic engineering techniques, is designed to detect changes in cTnI's neighboring protein, cardiac troponin T (cTnT). When there's a change...
Published: 5/13/2024
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Inventor(s): Romi Castillo, Jil Tardiff
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown...
Published: 7/6/2023
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Inventor(s): Rui Chang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
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Myofilament Based Therapeutics for Cardiac Muscle Arrhythmias and Skeletal Muscle Tremors
This invention describes a novel therapeutic approach to treat cardiac muscle arrhythmias and skeletal muscle tremors.
Background:
Cardiac arrhythmias, such as those that cause atrial fibrillation or sudden cardiac death (SCD), are typically viewed as electrical/conduction abnormalities that drive uncoordinated heartbeats and their downstream health...
Published: 7/26/2024
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Inventor(s): Samantha Harris
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences
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Materials Selection Criteria for Electrochemical Sensing Using Organic Electrochemical Transistor (OECT)
This technology is a new method for selecting materials when designing organic electrochemical transistors (OECTs). This method aides the design of OECT-based sensors, enabling optimization for operating power level and sensitivity.
Background:
OECTs are transistors useful in sensing and bioelectronics because they are simple, easy to manufacture,...
Published: 3/12/2024
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Inventor(s): Erin Ratcliff, Songyan Yu
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic
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Design Guideline of Floating Gate Electrolyte-Gated Transistor (FGEGT) Sensors
This technology is a method for designing floating gate electrolyte-gated transistor-based sensors, so that the sensor achieves a maximum sensitivity while maintaining a low operating voltage.
Background:
Electrolyte-gated transistors (EGTs) are a type of transistor particularly useful in biosensors due to their simplicity, sensitivity, low voltage...
Published: 3/12/2024
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Inventor(s): Erin Ratcliff, Songyan Yu
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Biologics
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A Peptide Approach to Block eNOS Phosphorylation at T495
This invention is a peptide that blocks eNOS phosphorylation. These peptides are designed to target the T495 phosporylation site of eNOS to prevent the activation of eNOS that leads to superoxide production and overwhelming inflammation. The initial peptide has been shown to reduce NOS derived superoxide and cell barrier loss throughout trials.
Background:
Pulmonary...
Published: 6/6/2024
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Inventor(s): Stephen Black, Evgeny Zemskov, Qing Lu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Biologics
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Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor
The core portion of the dynorphin protein was identified and modifications were made to that core to allow dynorphin to interact and antagonize a bradykinin receptor which is partially responsible for pain sensations.
Applications:
Since the invention antagonizes a receptor partly responsible for pain, the modified protein can be used as a form...
Published: 4/3/2023
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Inventor(s): Yeon Sun Lee
Keywords(s): ongoing pain
Category(s): Technology Classifications > Life Sciences > Biologics
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Artificial Membranes Incorporating GPCRs for Label-Free, Electrophysiological Measurements of Ligand-GPCR Interactions
This invention consists of an artificial lipid membrane that incorporates G-protein coupled receptors into its structure. It allows direct, label-free measurement of ligand binding and activation of G-protein coupled receptors.
Background:
G-protein coupled receptors are a superfamily of proteins that are very popular drug targets. In 2017, 34%...
Published: 3/12/2024
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Inventor(s): Steven Scott Saavedra, Craig Aspinwall
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Materials > Biomaterials, Technology Classifications > Research Tools > Screening assays
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