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New Therapeutic Strategy for Pancreatic Cancer with Wnt Inhibitors from Phenoxazine Derivatives
This invention is for a novel small molecule therapy for the treatment of Pancreatic ductal adenocarcinoma (PDAC). This new set of compounds contain inhibitors that have shown successfully slowed tumor progression by reducing expression of two major tumor-causing mutated oncoproteins in mouse models.
Background:
Pancreatic ductal adenocarcinoma (PDAC)...
Published: 3/24/2025
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Inventor(s): Daekyu Sun
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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Monofunctional MDM2 Degraders for Disease Treatment
This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors.
Background:
The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...
Published: 3/24/2025
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Inventor(s): Wei Wang, Jennifer Carew, Steffan Nawrocki, Mengyang Chang, Fangchao Bi
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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Kinase Suppressors for Cancer Therapy
Mixed Lineage Kinase 3 (MLK3) has been identified as a promising target for cancer therapy, particularly for addressing aggressive cancers such as triple-negative breast cancer (TNBC). TNBC is a challenging cancer type with limited treatment options and disproportionately affects certain populations. This innovative technology focuses on a series of...
Published: 3/17/2025
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Inventor(s): Gregory Thatcher, Ganga Reddy Velma, Rui Xiong
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Small Molecules
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Alternative Translation Initiation and Termination of Immunoglobulin (Ig) Folds (AltIg) for the Synthesis of Bifunctional Polypeptides
This invention is a novel way to create Alternative Igs (AltIgs). This invention could be used to fuse two proteins together as a single polypeptide by fusing the AltIg end of one protein to the other protein. This would create a different spatial relationship between the proteins than could be achieved if the native Ig was fused in a conventional manner.
Background:
Fusing...
Published: 3/5/2025
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Inventor(s): Michael Kuhns, Mark Lee, Deepta Bhattacharya
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Oncology
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Intracranial and Cerebrospinal Fluid Deuteration using Heavy Water Isotopologues
This invention is a method of therapeutic intervention for primary and metastatic brain cancer, and other relevant nervous system derivates, via the deliverances of deuterated heavy water isotopologue. This novel treatment method offers promise for specificity improvements as it uses water to deliver its therapy, allowing for increased efficiency in...
Published: 3/3/2025
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Inventor(s): Georg Wondrak, Jana Jandova
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics
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Endoglin Antibody
This technology is directed to an antibody to a mutated endoglin protein. Specifically, this antibody provides methods and compositions for detecting splice variants of the endoglin protein, enabling the accurate diagnosis of cancer. This invention further includes the use of endoglin-specific antibodies to enhance the detection process, offering a...
Published: 1/29/2025
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Inventor(s): Nam Lee
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Antibodies
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Cancer treatment through hTERT inhibition
Title: Cancer Treatment Through hTERT Inhibition Invention: The invention is a small molecule that reduces human telomerase reverse transcriptase (hTERT), which is highly activated in cancer cells. Background: In 2010, approximately 73,599 U.S. patients were diagnosed with melanoma with 8,700 of those incidences resulting in death. A hallmark of cancer,...
Published: 1/7/2025
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Inventor(s): Laurence Hurley, Vijay Gokhale, HyunJin Kang, Kui Wu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology
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Colorectal Cancer Prognostic/Prediction
This technology provides a gene score system to assess the effectiveness of antifibrotic treatments on colorectal cancer (CRC). By comparing gene expressions from colorectal cancer cells under two different types of mechanical conditioning, this system identifies specific gene signatures that correlate with an increased risk of metastasis and lower...
Published: 4/1/2025
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Inventor(s): Ghassan Mouneimne
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools
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Stainless Brush Biopsy for Epithelial Cells
This invention is a new approach to cervical cancer screening that removes the need for staining cervical specimens, leading to significant time and cost savings. Using a brush biopsy technique to collect cells from all layers of the cervix using a specialized brush, the specimen is spread on a slide and imaged using deep ultraviolet (dUVM) technology....
Published: 3/13/2025
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Inventor(s): Rongguang Liang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Reproductive Health: Obstetrics & Gynecology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
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Inhibition of Exosome Secretion in Triple Negative Breast Cancer
This invention is a new anti-cancer peptide for treatment of Triple-Negative Breast Cancer (TNBC). This new peptide-based therapeutic focuses on blocking of Epidermal Growth Factor Receptor (EGFR) and SNX1. In addition, this peptide blocks the secretion of harmful exosomes that further cancer cell metastasis and modulate the immune environment.
Background:...
Published: 12/16/2024
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Inventor(s): Joyce Schroeder, Ryan Hecksel, Abigail Camenisch, Delina Denogean, Josh Lederman
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Therapeutics
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