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CRISPR-Cas13-Based Isothermal Assay for Multiplex Detection of Circulating MicroRNAs from Small-Volume Blood Samples
This invention relates to the field of molecular diagnostics and nucleic acid detection. In particular, it concerns an isothermal assay platform for the multiplex detection of circulating microRNAs (miRNAs) in small-volume blood samples. The platform is useful for early detection, screening, or monitoring of diseases such as cancer and other conditions.
Background:...
Published: 2/16/2026
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Inventor(s): Ravi Goyal
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease
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Simultaneous Bilateral Breast Imaging without Compression using Offset Detector
This invention involves an upright cone-beam breast computed tomography (CT) designed to image two breasts simultaneously with high resolution. The design prevents patients from having to reposition their bodies between images. Additionally, this invention builds on the deep learning algorithm for breast CT image reconstruction.
Background:
Present...
Published: 2/13/2026
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Inventor(s): Hsin Wu Tseng, Srinivasan Vedantham
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Healthcare Portfolios > Radiology, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Diagnostics
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Inhibition of Metastasis in Triple Negative Breast Cancer
This invention uses a therapeutic peptide sequence that inhibits breast cancer metastasis by activating natural killer (NK) cells against breast cancer cells. This inhibitor can be used to treat triple-negative breast cancer metastasis, associated with excess epidermal growth factor receptor (EGRF) which is overexpressed and amplified in 60% of triple-negative...
Published: 1/21/2026
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Inventor(s): Joyce Schroeder
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Therapeutics
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Therapeutic Target of Ewing Sarcoma by G-Quadruplex Binding Compound
This innovation identified lead molecules that target specific nucleic acid structures involved with forming G-Quadruplex structures. These G-Quadruplex structures are a highly stable nucleic acid fold with planar stacks of guanine tetrads which regulate genome stability, transcription, and telomere maintenance. This innovation details a therapeutic...
Published: 1/6/2026
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Inventor(s): Jacob Schwartz, Haining Zhu, Ajibola Adelekun, Valery Thompson
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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Secretory Acid Sphingomyelinase Activity as a Diagnostic Marker in Colorectal Cancer
This invention utilizes the activity of secretory acid sphingomyelinase (S-SMase) in patient serum as a biomarker for the early or enhanced detection of colorectal neoplasia, including colorectal cancer (CRC).
Background:
Colorectal cancer (CRC) is one of the most common cancers worldwide, ranking third in incidence and second in cancer-related deaths...
Published: 9/22/2025
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Inventor(s): Ashley Snider, Nathan Ellis, Justin Snider, Peter Lance
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Diagnostics
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Lipid-Based Diagnostic for Minimally-Invasive Screening and Early Detection of Gynecologic Cancer
This invention is a non-invasive diagnostic for the screening and early detection of gynecologic cancers, including endometrial, cervical, and ovarian cancer, based on a lipid panel. It analyzes cervicovaginal lavages for key biomarkers that could ultimately be used a screening technology as a part of a well-woman exam to assess the risk of gynecologic...
Published: 9/22/2025
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Healthcare Portfolios > Reproductive Health: Obstetrics & Gynecology, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
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Biomarker for the Classification of Melanocytic Neoplasms
This invention relates to potential transcriptomic biomarkers using gene- or protein-level expression of individual or a combination of the 23 genes/proteins to accurately differentiate between low-risk, benign from high-risk, malignant melanocytic neoplasms. This approach aims to improve the accuracy of melanoma diagnosis and reduce diagnostic uncertainty.
Background:...
Published: 10/15/2025
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Inventor(s): Karen Hastings, Elizabeth Borden, Bonnie LaFleur
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
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Diagnostic for Prostate Cancer Treatment Outcomes
This technology offers a novel diagnostic tool that predicts prostate cancer treatment outcomes using a chromosomal instability signature based on nine genes. Developed through a multi-omics approach, this signature was identified in prostate epithelial cells experiencing transient centrosome loss—an event known to drive chromosomal instability...
Published: 9/8/2025
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Inventor(s): Gregory Rogers, Megha Padi, Jiawen Yang, John Ryniawec
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Urology, Technology Classifications > Life Sciences > Diagnostics
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Modifying the Gastric Tumor Microenvironment with Tadalafil
This technology leverages phosphodiesterase 5 (PDE5) inhibitors—such as tadalafil and sildenafil—in combination with the standard of care to treat gastric adenocarcinomas (GAC). The use of PDE5 inhibitors has the potential to enhance immune response and treatment outcomes with a well-established safety profile.
Background:
Gastric adenocarcinoma...
Published: 9/2/2025
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Inventor(s): Juanita Merchant
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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New Therapeutic Strategy for Pancreatic Cancer with Wnt Inhibitors from Phenoxazine Derivatives
This invention is for a novel small molecule therapy for the treatment of Pancreatic ductal adenocarcinoma (PDAC). This new set of compounds contain inhibitors that have shown successfully slowed tumor progression by reducing expression of two major tumor-causing mutated oncoproteins in mouse models.
Background:
Pancreatic ductal adenocarcinoma (PDAC)...
Published: 3/24/2025
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Inventor(s): Daekyu Sun
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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