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Secretory Acid Sphingomyelinase Activity as a Diagnostic Marker in Colorectal Cancer
This invention utilizes the activity of secretory acid sphingomyelinase (S-SMase) in patient serum as a biomarker for the early or enhanced detection of colorectal neoplasia, including colorectal cancer (CRC).
Background:
Colorectal cancer (CRC) is one of the most common cancers worldwide, ranking third in incidence and second in cancer-related deaths...
Published: 9/22/2025
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Inventor(s): Ashley Snider, Nathan Ellis, Justin Snider, Peter Lance
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Diagnostics
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Lipid-Based Diagnostic for Minimally-Invasive Screening and Early Detection of Gynecologic Cancer
This invention is a non-invasive diagnostic for the screening and early detection of gynecologic cancers, including endometrial, cervical, and ovarian cancer, based on a lipid panel. It analyzes cervicovaginal lavages for key biomarkers that could ultimately be used a screening technology as a part of a well-woman exam to assess the risk of gynecologic...
Published: 9/22/2025
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Healthcare Portfolios > Reproductive Health: Obstetrics & Gynecology, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
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Biomarker for the Classification of Melanocytic Neoplasms
This invention relates to potential transcriptomic biomarkers using gene- or protein-level expression of individual or a combination of the 23 genes/proteins to accurately differentiate between low-risk, benign from high-risk, malignant melanocytic neoplasms. This approach aims to improve the accuracy of melanoma diagnosis and reduce diagnostic uncertainty.
Background:...
Published: 10/7/2025
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Inventor(s): Karen Hastings, Elizabeth Borden, Bonnie LaFleur
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
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Diagnostic for Prostate Cancer Treatment Outcomes
This technology offers a novel diagnostic tool that predicts prostate cancer treatment outcomes using a chromosomal instability signature based on nine genes. Developed through a multi-omics approach, this signature was identified in prostate epithelial cells experiencing transient centrosome loss—an event known to drive chromosomal instability...
Published: 9/8/2025
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Inventor(s): Gregory Rogers, Megha Padi, Jiawen Yang, John Ryniawec
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Urology, Technology Classifications > Life Sciences > Diagnostics
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Modifying the Gastric Tumor Microenvironment with Tadalafil
This technology leverages phosphodiesterase 5 (PDE5) inhibitors—such as tadalafil and sildenafil—in combination with the standard of care to treat gastric adenocarcinomas (GAC). The use of PDE5 inhibitors has the potential to enhance immune response and treatment outcomes with a well-established safety profile.
Background:
Gastric adenocarcinoma...
Published: 9/2/2025
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Inventor(s): Juanita Merchant
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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New Therapeutic Strategy for Pancreatic Cancer with Wnt Inhibitors from Phenoxazine Derivatives
This invention is for a novel small molecule therapy for the treatment of Pancreatic ductal adenocarcinoma (PDAC). This new set of compounds contain inhibitors that have shown successfully slowed tumor progression by reducing expression of two major tumor-causing mutated oncoproteins in mouse models.
Background:
Pancreatic ductal adenocarcinoma (PDAC)...
Published: 3/24/2025
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Inventor(s): Daekyu Sun
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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Monofunctional MDM2 Degraders for Disease Treatment
This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors.
Background:
The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...
Published: 3/24/2025
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Inventor(s): Wei Wang, Jennifer Carew, Steffan Nawrocki, Mengyang Chang, Fangchao Bi
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
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Kinase Suppressors for Cancer Therapy
Mixed Lineage Kinase 3 (MLK3) has been identified as a promising target for cancer therapy, particularly for addressing aggressive cancers such as triple-negative breast cancer (TNBC). TNBC is a challenging cancer type with limited treatment options and disproportionately affects certain populations. This innovative technology focuses on a series of...
Published: 3/17/2025
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Inventor(s): Gregory Thatcher, Ganga Reddy Velma, Rui Xiong
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Small Molecules
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Alternative Translation Initiation and Termination of Immunoglobulin (Ig) Folds (AltIg) for the Synthesis of Bifunctional Polypeptides
This invention is a novel way to create Alternative Igs (AltIgs). This invention could be used to fuse two proteins together as a single polypeptide by fusing the AltIg end of one protein to the other protein. This would create a different spatial relationship between the proteins than could be achieved if the native Ig was fused in a conventional manner.
Background:
Fusing...
Published: 3/5/2025
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Inventor(s): Michael Kuhns, Mark Lee, Deepta Bhattacharya
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Oncology
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Intracranial and Cerebrospinal Fluid Deuteration using Heavy Water Isotopologues
This invention is a method of therapeutic intervention for primary and metastatic brain cancer, and other relevant nervous system derivates, via the deliverances of deuterated heavy water isotopologue. This novel treatment method offers promise for specificity improvements as it uses water to deliver its therapy, allowing for increased efficiency in...
Published: 3/3/2025
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Inventor(s): Georg Wondrak, Jana Jandova
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics
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