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Stainless Brush Biopsy for Epithelial Cells
This invention is a new approach to cervical cancer screening that removes the need for staining cervical specimens, leading to significant time and cost savings. Using a brush biopsy technique to collect cells from all layers of the cervix using a specialized brush, the specimen is spread on a slide and imaged using deep ultraviolet (dUVM) technology....
Published: 10/21/2024
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Inventor(s): Rongguang Liang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Reproductive Health: Obstetrics & Gynecology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
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Inhibition of Exosome Secretion in Triple Negative Breast Cancer
This invention is a new anti-cancer peptide for treatment of Triple-Negative Breast Cancer (TNBC). This new peptide-based therapeutic focuses on blocking of Epidermal Growth Factor Receptor (EGFR) and SNX1. In addition, this peptide blocks the secretion of harmful exosomes that further cancer cell metastasis and modulate the immune environment.
Background:...
Published: 11/14/2024
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Inventor(s): Joyce Schroeder, Ryan Hecksel, Abigail Camenisch, Delina Denogean, Josh Lederman
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Therapeutics
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Cholesterol-modified Sphingomyelin Lipid Bilayer for Drug and Gene Delivery
This invention is a new type of lipid vesicle or liposome that can be used to encapsulate drugs and genes for therapeutic applications. It improves upon existing liposome formulations in its increased stability, subsequent increased circulation time, and effectiveness as a nanocarrier.
Background:
For many years, therapeutic drugs were released...
Published: 7/24/2024
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Inventor(s): Jianqin Lu, Zhiren Wang, Wenpan Li
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Healthcare Portfolios > Oncology
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Breast Density Bioelectrical Impedance Device Attachment
This technology is a device which applies bioelectrical impedance (BIA) principles to the breast for an estimate of breast density in order to provide a new screening tool for detection of breast cancer. BIA technology is applied to the limited area of breast as opposed to whole body measurements commonly used to assess adiposity. The goal of the breast...
Published: 8/9/2024
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Inventor(s): Jennifer Bea
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Medical Devices > Diagnostic
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Synthesis of Novel Au(II) Dimers and Investigation of their Potential for Applications in Cancer Treatment
This invention is a method of synthesis of novel Au(II) dimer with pyridine dipyrrolinone (H2PYDP) ligands which demonstrate antiproliferative activity in ovarian cancers. This compound operates with a different mechanism than similar existing drugs allowing for novel combinational drug therapies to be created and tested.
Background:
It is estimated...
Published: 7/8/2024
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Inventor(s): Elisa Tomat, Iva Habensus, Yu-Shien Sung
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health
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Identification of Inhibitors of Trogocytosis to Treat Cancer
This innovation is the identification and isolation of small molecules to inhibit trogocytosis to prevent or slow cancer cell tumor growth. Researchers plan to develop cell lines transduced with lentivirus vectors that can be cocultured and the process of trogocytosis will result in cell fusion that will generate a luminescent signal. Selected small...
Published: 6/3/2024
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Inventor(s): Alfred Bothwell, Haley Marcarian, Anutr Sivakoses
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers
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Transplantable Murine Cutaneous Squamous Cell Carcinoma Cell Lines
This innovation involves the creation of novel cell lines for studying cutaneous squamous cell carcinoma (cSCC) in mice. These cell lines, derived from UV-induced cSCC tumors in BALB/c mice, recapitulate the mutational signature and driver mutations found in human cSCC. Developing the cell lines from an inbred mouse strain allows for studies involving...
Published: 5/20/2024
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Inventor(s): Karen Hastings, Anngela Adams, Anne Macy
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Healthcare Portfolios > Dermatology, Technology Classifications > Healthcare Portfolios > Oncology
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Pharmacological Inhibition of PD-L1 as an Antagonist of Skin Damage and Cancer in response to Acute and Chronic Solar UV Exposure and Other Environmental Toxicants
This innovation is the development of a pharmacological inhibitor of PD-L1 to prevent or reduce the negative impact of acute and chronic solar UV exposure and environmental toxicants on the skin. PD-L1 is a molecule involved in immune regulation and can be upregulated in response to UV radiation and environmental toxins. However, overexpression of PD-L1...
Published: 7/26/2024
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Inventor(s): Sally Dickinson, Georg Wondrak, Clara Curiel
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Dermatology
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Methods and System for Closed-Loop Ultrasound and Photoacoustic Imaging
This technology is a novel closed-loop volumetric ultrasound and photoacoustic imaging and spectroscopy method that is operator-independent. The technology can be integrated with existing hardware systems, and it offers the flexibility to scale from standard clinical ultrasound to high-frequency preclinical imaging for visualizing structures at different...
Published: 1/16/2024
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Inventor(s): Russell Witte, Eric Reichel, Clara Curiel, Christopher Salinas, Delaney Stratton
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Dermatology
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Bioorthogonal Activation of PROTAC Prodrugs
Utilizing proteolysis targeting chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has become a potential therapeutic strategy for cancer. This innovation is an on-demand prodrug strategy called click-release proteolysis targeting chimeras, or “crPROTACs.” The crPROTACs strategy utilizes bioorthogonal chemistry and...
Published: 1/16/2024
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Inventor(s): Wei Wang, Mengyang Chang, Giri Gnawali
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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