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DNA as an Antimicrobial Agent for Preventing Neisseria Gonorrhoeae Infection
This invention encompasses a series of DNA-based antimicrobial compounds that prevent transmission of Neisseria gonorrhoeae (Ngo) during sexual intercourse and possibly treat an extant Ngo infection, alone or in combination with antibiotics, while leaving commensals unharmed. These DNA molecules are effective against low-passage antibiotic sensitive...
Published: 9/25/2024
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Inventor(s): Maria Rendon, Magdalene So
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Reproductive Health: Obstetrics & Gynecology, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Automatic Toilet Disinfectant Dispenser for Public Toilets
This invention is an innovative automatic disinfectant dispenser designed for use in public restrooms. This simple yet effective device aims to reduce the risk of disease transmission by ensuring consistent sanitation of toilet surfaces. The dispenser releases a controlled amount of disinfectant, such as sodium hypochlorite (bleach) tablets, which are...
Published: 8/26/2024
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Inventor(s): Charles Gerba
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Energy, Cleantech & Environmental > Air/Water Purification
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Coronavirus Therapeutics
This technology introduces a potent covalent enzyme inhibitor designed specifically for targeting the cysteine protease, PLpro, a key player in the replication process of SARS coronaviruses like SARS-CoV-2 and MERS. Unlike traditional small molecule inhibitors, this inhibitor offers unparalleled efficacy and specificity, making it a promising candidate...
Published: 6/5/2024
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Inventor(s): Rui Xiong, Gregory Thatcher, Divakar Indukuri, Kiira Ratia, Li jun Rong
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Phenyllactic Acid: Antimicrobial Activity against Vaginal Microbiota and Cytotoxic Properties on Human Cervical Epithelial Cells
Researchers at the University of Arizona investigated the antimicrobial properties of Phenyllactic Acid (PLA) derivatives against both commensal and Bacterial vaginosis (BV)-associated bacteria, as well as their cytotoxic effects on human cervical epithelial cells. PLA is a broad-spectrum antimicrobial compound produced by vaginal Lactobacillus species;...
Published: 11/6/2024
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Inventor(s): Melissa Herbst-Kralovetz, Pawel Laniewski, Abhijit Date, Phoebe Crossley, Yogesh Sutar
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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Small Molecules with Antifungal Activity for Cryptococcosis
Researchers at the University of Arizona have found 140 novel antifungal compounds with the potential to treat cryptococcosis. These compounds have anti-Cryptococcus neoformans activity with IC50 less than 10 uM.
Background:
Fungal infections, although not very contagious, have affected 300 million people worldwide. Cryptococcosis is caused by opportunistic...
Published: 1/10/2024
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Inventor(s): Hongmin Li, Anil Tharappel, Zhong Li
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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A Broad Spectrum Antimicrobial that Synergizes with Copper
University of Arizona researchers have developed an invention that synergizes with copper to kill and prevent further growth of a broad spectrum of pathogens (i.e both Streptococcus pneumoniae and Valley Fever with the potential to work on other pathogens). This therapy does not allow for resistance to be built by the microbes.
Published paper with...
Published: 1/5/2024
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Inventor(s): Michael Johnson, Joseph Alvin, Angela Rivera, Wei Wang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics
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Broad Spectrum Inhibitors against Viral Methyltransferases
This innovation is a universal high throughput screening (HTS) assay to identify inhibitors targeting a binding site of viral methyltransferases (MTases) with a methyl donor. The inventors developed a fluorescence polarization (FP)-based HTS assay to target reference MTases, an essential enzyme to methylate the 5’-cap of viral RNA genome on SARS-CoV-2...
Published: 11/16/2023
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Inventor(s): Hongmin Li, Zhong Li
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Novel Modalities for the Treatment of Cryptococcal Meningitis
This invention is the repurposing of oxfendazole, an FDA-approved veterinary anthelmintic benzimidazole and its novel oral bioavailability enhancing formulations for the oral treatment of cryptococcal meningitis. The oxfendazole ionic liquid containing nano formulations can lead to the development of low-cost oral treatment for cryptococcal meningitis.
Background:...
Published: 6/21/2024
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Inventor(s): Abhijit Date, Yogesh Sutar, Kirsten Nielsen, Sophie Fulton
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Drug Delivery
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Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/1/2024
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Inventor(s): Hongmin Li, subodh samrat, Zhong Li, Jia Zhou, Jimin Xu
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 2/13/2024
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Inventor(s): Hongmin Li, Zhong Li, Qing-yu Zhang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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