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StellarScape - Immersive Multimedia Performances, Experiences, and Installations
StellarScape is a combination of music, dance, and cinematography, blended with state-of-the-art data visualization and astrophysical simulation. StellarScape is not only an immersive multimedia performance synthesizing music, science, visual art, and technology, but also an interactive audiovisual installation/experience that allows the visitors to...
Published: 10/25/2023
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Inventor(s): Yuanyuan He, Winslow Burleson, Christopher Impey
Keywords(s):
Category(s): Technology Classifications > Creative Works, Technology Classifications > Software & Information Technology > Computer-Aided Design & Engineering, Technology Classifications > Sensors & Controls > Motion & Force, Technology Classifications > Software & Information Technology
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Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/1/2024
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Inventor(s): Hongmin Li, subodh samrat, Zhong Li, Jia Zhou, Jimin Xu
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Natural Compounds to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease.
Background:
Alzheimer’s disease (AD) is the most common form of dementia estimated to affect 36 million people worldwide and an estimated 115 million people by 2050. While doctors still don’t know the cause of AD, treatments...
Published: 6/3/2023
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Inventor(s): Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences
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Combinations for the Treatment of Neurodegeneration
Researchers at the University of Arizona have researched new formulations and combinations of compounds for the treatment of Alzheimer’s disease. Developing a novel computational system allowed the inventors to identify several therapeutic targets of single cell type and whole bulk tissue that contribute to Alzheimer's disease. These therapeutic...
Published: 4/3/2023
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Inventor(s): Rui Chang, Patrick Ronaldson, Wei Wang, Vijayan Ramachandran, Yanyun Liu, Qianying He
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences
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Stem Cell Fusion Model of Carcinogenesis
This technology is a method for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell.
Background:
Cancer has been difficult to treat because of tissue heterogeneity and gene instability....
Published: 4/3/2023
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Inventor(s): David Harris, Tom Tsang, Brian Pipes, Xianghui He
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Stem Cells
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Pharmaceutical and Nutraceutical Formulation Therapeutics for Alzheimer's Disease
This invention is a new formulation for the treatment of Alzheimer’s Disease. Through the application of a novel computational systems biology approach, the inventors have identified several therapeutic targets of single cell type and whole bulk tissue that contribute to Alzheimer’s Disease, which can be used individually or in combination...
Published: 6/3/2023
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Inventor(s): Rui Chang, Patrick Ronaldson, Qianying He
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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Conjugation of the MCR1 Ligand with Cytotoxic Drugs for Targeted Melanoma Therapy
University of Arizona researchers have developed a drug composition and method of cancer treatment using chemotherapeutics linked to ligands selective for uptake by melanocortin 1 receptors (MC1R) in MC1R-overexpressing melanoma. This development targets melanoma, and may be used with a wide range of cytotoxic drugs, to selectively deliver a toxic payload...
Published: 3/12/2024
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Inventor(s): Minying Cai, Victor Hruby, Yang Zhou
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Dermatology, Technology Classifications > Healthcare Portfolios > Oncology
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Enzymatically Released Aryl Diazonium Ions
This invention is the discovery of triazebutadienes that rapidly release aryl diazonium ions at neutral pH with a half-life of approximately one minute.
Background:
In 2015, the global protein therapeutics market grew to nearly $174.7 billion due to trends in targeted therapies that resulted in fewer side effects. Monoclonal antibodies and biologics...
Published: 3/12/2024
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Inventor(s): John Jewett, Lindsay Guzman, Bereketab Mehari, Jie He
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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Smart Carpet: System and Methods to Automatically Recognize and Track Physical and Physiological Activities for Healthcare
This technology is a carpet with various sensors embedded within it to monitor and track a patient's movement. The carpet provides information regarding frailty, risk of falling, outcomes of rehabilitation, effects of plantar wound healing, and emergencies such as sudden falling due to heart attack.
Background:
The U.S. is expected to have more...
Published: 4/3/2023
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Inventor(s): Bijan Najafi, Hyoki Lee, He Zhou
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Medical Devices > Diagnostic
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Reactive Oxygen Species Gene Signature Predicts Survival in Sepsis
This technology is a 21-gene reactive oxygen species (ROS)-associated molecular signature that predicts survival in septic patients. This particular signature has outperformed randomly generated signatures of the same signature gene size. This signature is easily assayed from peripheral blood and can potentially predict.
Background:
There is a significant...
Published: 11/16/2023
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Inventor(s): Louise Hecker, Marvin Slepian, Christian Bime, Tong Zhou, Nima Pouladi, Ting Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics
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