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Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023
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Inventor(s): Leilei Peng, Yu Li, Han Zhang
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
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Novel Compounds Inhibiting COVID-19 Replication
This technology is three potential pharmacological treatment options for COVID-19. The inventors identified three compounds, two naturally occurring and one small-molecule. These compounds target and inhibit the main 3CL protease that is essential to the replication of SARS-CoV-2 and have been shown to be effective against the virus in vitro.
Background:
In...
Published: 4/3/2023
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Inventor(s): Rui Chang, Dominik Schenten, Patrick Ronaldson, Yanyun Liu, Vijayan Ramachandran
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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Combinations for the Treatment of Neurodegeneration
Researchers at the University of Arizona have researched new formulations and combinations of compounds for the treatment of Alzheimer’s disease. Developing a novel computational system allowed the inventors to identify several therapeutic targets of single cell type and whole bulk tissue that contribute to Alzheimer's disease. These therapeutic...
Published: 4/3/2023
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Inventor(s): Rui Chang, Patrick Ronaldson, Wei Wang, Vijayan Ramachandran, Yanyun Liu, Qianying He
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences
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Cell Cycle Nucleic Acids, Polypeptides and Uses Thereof - Wee1
This invention improves transformation frequency by changing levels of protein expression in the target cells, altering the cell cycle, specifically by modulating the activity of a gene known as RB3 which influences the cell's progression from G1 to S phase in the cell cycle. Overexpression of RB3 can be induced through existing methods of transient...
Published: 4/3/2023
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Inventor(s): Paolo Sabelli, Yan Liu, Chunsheng Zhang, William Gordon-Kamm, Keith Lowe, Matthew Bailey, Xun Wang, Carolyn Gregory, George Hoerster, John Mcelver, Shane Abbitt, Benjamin Bowen, Brian Larkins, Brian Dilkes, Ricardo Dante, Yeujin Sun
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > Therapeutics
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Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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