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Fast Volumetric Imaging of Fluorescent Tissue Structures and Activities
Researchers at the University of Arizona have developed a novel microscope imaging technique that generates high-resolution large-volume 3D images of tissue at subcellular resolution, and captures transient activities within the volume at 100 volume frames per second (vps). The invention breaks away from the traditional plane-scanning approach and implements...
Published: 2/28/2024
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Inventor(s): Leilei Peng, Jun Ding, Dongli XU
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
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Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023
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Inventor(s): Leilei Peng, Yu Li, Han Zhang
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
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Method of Simultaneous Frequency-Sweeping Lifetime Measurements on Multiple Excitation Wavelengths
A new lifetime imaging system that can fully measure the FRET network between five fluorescent labels in a single image scan has been developed at the University of Arizona. This technology is capable of performing hyper-dimensional lifetime imaging on multiple excitation wavelengths simultaneously, allowing for previously not achievable FRET imaging...
Published: 4/3/2023
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Inventor(s): Leilei Peng, Ming Zhao
Keywords(s): fluorescence lifetime, frequency-sweeping
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry, Technology Classifications > Imaging & Optics
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Method of Measuring Distorted Illumination Patterns and Correcting Image Artifacts in Structured Illumination Imaging
This technology is an improvement to the well-established microscopy technique structured illumination microscopy (SIM), which uses a periodic structured pattern of light to image a sample. In SIM, it is common for artifacts to arise during imaging, because the pattern is often distorted due to aberration and index mismatches in samples. These artifacts...
Published: 7/6/2023
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Inventor(s): Leilei Peng
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
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