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Scalable Synthesis for Commercial Production of Carbohydrate-Based Molecular Scaffold Compounds for Direct Delivery of Drugs or Nutritional Supplements to the GI Tract
This invention provides a scalable synthesis method for commercial production (kilogram and greater) of novel carbohydrate-based molecular scaffold compounds for various therapeutic and diagnostic applications that have been and are being developed by UArizona inventors. Oral administration and targeted delivery of pro-drugs or other payloads, such...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr.
Keywords(s):
Category(s): Technology Classifications > Materials > Processing, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Nutraceuticals
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Design and Synthesis of Pro-Drugs for Selective, Oral Delivery to the Gastrointestinal Tract
This invention provides a method for oral administration and targeted delivery of pro-drugs bonded to a carbohydrate-based molecular scaffold to the gastrointestinal tract, where the pro-drug is released directly in the gastrointestinal (GI) tract by nitroreductase enzymes naturally present. This technology provides a means of delivery of GI therapies...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Pawel Kiela
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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Novel 5-Fluorouracil Prodrug For Colorectal Cancer Therapy
This invention provides a method for a targeted delivery of a commonly used chemotherapy drug, 5-fluorouracil used to treat colorectal cancer. A pro-drug is released within the colon to release the active ingredient. The method will allow for targeted delivery of 5-fluorouracil to the colon.
Background:
Colorectal cancer is the third most commonly...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Pawel Kiela
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology
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Sucrose-Derived Scaffold For Gd MRI Contrast Agent And Method For Use In Colon Cancer Screening
This invention is a targeted molecular imaging agent to be used in conjunction with MRI or CT. It is designed especially for the early and specific detection of colorectal cancer. The formulation of this novel contrast agent allows for non-invasive imaging of the entire colon, with excellent soft-tissue contrast.
Background:
The key to high survival...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Medical Devices > Diagnostic
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A Molecular Scaffold for Colonic Drug Delivery
A molecule which passes through the gastrointestinal tract was successfully synthesized and tested for GI MRI imaging in mice. A molecular scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. This contrast agent...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan, Suryakiran Navath, Venkataramana Rao, Rita Marie Woodford, Monica Midura-Kiela, Ahad Ali, Ramesh Alleti
Keywords(s): 5-aminosalicylic acid, gastrointestinal tract, inflammatory bowel disease, pro-drug
Category(s): Technology Classifications > Life Sciences > Diagnostics
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Imaging Agents for Detection and Treatment of Breast Cancer
This invention is a breast cancer metastasis-targeting agent capable of identifying boundaries between normal and diseased tissues. These synthesized agents will bind to tumor cells, allowing surgeons to reliably remove diseased tissues.
Background:
Surgical biopsy of the sentinel lymph nodes (SLN) is an invasive and expensive burden for patients....
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., David Morse
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Healthcare Portfolios > Oncology
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Urinalysis Test for a Compromised Gastrointestinal Tract
This technology is an orally administered compound that identifies a compromised gastrointestinal tract, especially in diseases that cause "leaks" in to the blood. If the GI tract is compromised, the compound will be found in the urine and a simple urinalysis can be completed. If the individual is healthy the compound will be expelled in the...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Life Sciences > Diagnostics
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A GI-Specific Contrast Agent for Magnetic Resonance Imaging
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition in this invention. This contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Suryakiran Navath, Venkataramana Rao, Ramesh Alleti, Ahad Ali, Gary Martinez, Robert Gillies, David Morse
Keywords(s): contrast agent, gastrointestinal tract, MRI
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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Targeted Drug Delivery in the Gastrointestinal Tract, including for Inflammatory Bowel Disease
This invention is a scaffold molecule and a method for using the molecule to deliver active drug molecules to targets in the body. The sucrose-derived scaffold molecule delivers the drug to target sites and releases the drug molecules based on environmental factors, which improves efficacy and reduces side effects.
Background:
Throughout their research,...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics
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Solvent-Free and Additive-Free Nitration of Arenes
University of Arizona researchers have developed a novel, one-step, catalyst-free, and solvent-free synthetic process for the nitration of aromatic compounds. This method has been used to prepare 2,4-dinitroanisole, an alternative to trinitrotoluene (TNT), as an ingredient in melt-cast explosive formulations; and dinitrophenyl ethers. This synthetic...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Bhumasamudram Jagadish
Keywords(s):
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Life Sciences > Small Molecules
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