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A Molecular Scaffold for Colonic Drug Delivery
A molecule which passes through the gastrointestinal tract was successfully synthesized and tested for GI MRI imaging in mice. A molecular scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. This contrast agent...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan, Suryakiran Navath, Venkataramana Rao, Rita Marie Woodford, Monica Midura-Kiela, Ahad Ali, Ramesh Alleti
Keywords(s): 5-aminosalicylic acid, gastrointestinal tract, inflammatory bowel disease, pro-drug
Category(s): Technology Classifications > Life Sciences > Diagnostics
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A GI-Specific Contrast Agent for Magnetic Resonance Imaging
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition in this invention. This contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Suryakiran Navath, Venkataramana Rao, Ramesh Alleti, Ahad Ali, Gary Martinez, Robert Gillies, David Morse
Keywords(s): contrast agent, gastrointestinal tract, MRI
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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A Novel Gd-Sucrose Scaffold for Oral Administration in MR-Colonography at 7 T
This invention is a Gadolinium-DOTA sucrose-derived agent synthesized with eight Gadolinium-DOTA chelates per sucrose and a molecular structure to induce stiffness and increase the rotational correlation time. For in vivo assessment, SCID mice were intra-rectally injected with human CRC cells. Then, the mice received the Gadolinium-DOTA sucrose-derived...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Parastou Foroutan, Suryakiran Navath, Robert Gillies, Gary Martinez, David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Radiology
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