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A GI-Specific Contrast Agent for Magnetic Resonance Imaging
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition in this invention. This contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Suryakiran Navath, Venkataramana Rao, Ramesh Alleti, Ahad Ali, Gary Martinez, Robert Gillies, David Morse
Keywords(s): contrast agent, gastrointestinal tract, MRI
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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A Novel Gd-Sucrose Scaffold for Oral Administration in MR-Colonography at 7 T
This invention is a Gadolinium-DOTA sucrose-derived agent synthesized with eight Gadolinium-DOTA chelates per sucrose and a molecular structure to induce stiffness and increase the rotational correlation time. For in vivo assessment, SCID mice were intra-rectally injected with human CRC cells. Then, the mice received the Gadolinium-DOTA sucrose-derived...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Parastou Foroutan, Suryakiran Navath, Robert Gillies, Gary Martinez, David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Radiology
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Molecular Imaging of Cancer Cells in Vivo
This technology is a non-invasive method of detecting cancer using in vivo probes that target and bind to receptor cites on or around the cancerous growth.
Applications:
Cancer detection - identify and confirm possible tumors
Optical imaging probe
Advantages:
As an optical imaging probe, there is a high sensitivity for ligand detection and...
Published: 4/3/2023
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Inventor(s): Josef Vagner, Amanda Huynh, Robert Gillies, David Morse
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biomarkers
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All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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