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Inhibitors of the DNA - KU70/80 Association to Sensitize Cells for Radiation or Chemotherapy
This invention provides methods and compositions for inhibiting cancer cell survival and/or promoting cell death following radiation or chemotherapy applied in cancer treatment. This invention is a second set of Ku70/80 inhibitors that can sensitize cancer cells for chemotherapy. A first set of Ku70/ 80 inhibitors was previously discovered by University...
Published: 4/3/2023
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Inventor(s): Eric Weterings, Daruka Mahadevan, Josef Vagner
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Toll-like Receptor 2 Ligands and Methods of Making and Using Thereof
Inventors at the University of Arizona have developed a set of 13 high-affinity toll-like receptor 2 (TLR2) agonists. In certain diseases, particularly pancreatic cancer, these receptors are overexpressed. TLR2 agonists are absorbed by these receptors. When the ligands are labeled with fluorescent proteins, the tumors can be identified. Additionally,...
Published: 4/3/2023
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Inventor(s): Josef Vagner, Mark Mclaughlin, David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biologics
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PAR3 Inhibitors as Therapeutic for Pain
This technology identifies protease activated receptor-3 (PAR3) and PAR3 inhibitors as a novel target for the treatment of pain.
Background:
Pain is one of the most common reasons in which individuals seek medical attention. Globally, pain affects at least 1.5 billion people, with the incidence rate increasing complementary to age. Current treatments...
Published: 4/3/2023
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Inventor(s): Josef Vagner, Scott Boitano, Theodore Price, Greg Dussor
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Anesthesiology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Small Molecules
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Small Molecular Weight Inhibitors of the DNA - KU70/80 Association to Sensitize Cells for Radiation or Chemotherapy
This invention provides methods and compositions for inhibiting cancer cell survival and/or promoting cell death following radiation or chemotherapy applied in cancer treatment. This invention can be used to treat cancer alone as well. University of Arizona investigators found compounds that may disrupt the Ku70/80 – DNA repair association. The...
Published: 4/3/2023
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Inventor(s): Eric Weterings, Daruka Mahadevan, Josef Vagner
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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Molecular Imaging of Cancer Cells in Vivo
This technology is a non-invasive method of detecting cancer using in vivo probes that target and bind to receptor cites on or around the cancerous growth.
Applications:
Cancer detection - identify and confirm possible tumors
Optical imaging probe
Advantages:
As an optical imaging probe, there is a high sensitivity for ligand detection and...
Published: 4/3/2023
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Inventor(s): Josef Vagner, Amanda Huynh, Robert Gillies, David Morse
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biomarkers
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