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Breast Tumor Targeted Fluorescence Guidance for Intraoperative Margin Assessment
This technology is an anti-CEACAM6 antibody tagged with fluorescent labels. The idea is that these fluorescent antibodies can be used for real-time molecular fluorescence imaging to help guide the surgical removal of a tumor. This technology is targeted toward breast cancer.
Background:
Over half of the 270,000 breast cancer diagnoses in the United...
Published: 4/3/2023
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Inventor(s): Daruka Mahadevan, David Morse
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Oncology
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Sucrose-Derived Scaffold For Gd MRI Contrast Agent And Method For Use In Colon Cancer Screening
This invention is a targeted molecular imaging agent to be used in conjunction with MRI or CT. It is designed especially for the early and specific detection of colorectal cancer. The formulation of this novel contrast agent allows for non-invasive imaging of the entire colon, with excellent soft-tissue contrast.
Background:
The key to high survival...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Medical Devices > Diagnostic
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Imaging Agents for Detection and Treatment of Breast Cancer
This invention is a breast cancer metastasis-targeting agent capable of identifying boundaries between normal and diseased tissues. These synthesized agents will bind to tumor cells, allowing surgeons to reliably remove diseased tissues.
Background:
Surgical biopsy of the sentinel lymph nodes (SLN) is an invasive and expensive burden for patients....
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., David Morse
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Healthcare Portfolios > Oncology
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Urinalysis Test for a Compromised Gastrointestinal Tract
This technology is an orally administered compound that identifies a compromised gastrointestinal tract, especially in diseases that cause "leaks" in to the blood. If the GI tract is compromised, the compound will be found in the urine and a simple urinalysis can be completed. If the individual is healthy the compound will be expelled in the...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Life Sciences > Diagnostics
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A GI-Specific Contrast Agent for Magnetic Resonance Imaging
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition in this invention. This contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Suryakiran Navath, Venkataramana Rao, Ramesh Alleti, Ahad Ali, Gary Martinez, Robert Gillies, David Morse
Keywords(s): contrast agent, gastrointestinal tract, MRI
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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Toll-like Receptor 2 Ligands and Methods of Making and Using Thereof
Inventors at the University of Arizona have developed a set of 13 high-affinity toll-like receptor 2 (TLR2) agonists. In certain diseases, particularly pancreatic cancer, these receptors are overexpressed. TLR2 agonists are absorbed by these receptors. When the ligands are labeled with fluorescent proteins, the tumors can be identified. Additionally,...
Published: 4/3/2023
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Inventor(s): Josef Vagner, Mark Mclaughlin, David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biologics
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A Novel Gd-Sucrose Scaffold for Oral Administration in MR-Colonography at 7 T
This invention is a Gadolinium-DOTA sucrose-derived agent synthesized with eight Gadolinium-DOTA chelates per sucrose and a molecular structure to induce stiffness and increase the rotational correlation time. For in vivo assessment, SCID mice were intra-rectally injected with human CRC cells. Then, the mice received the Gadolinium-DOTA sucrose-derived...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Parastou Foroutan, Suryakiran Navath, Robert Gillies, Gary Martinez, David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Radiology
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Molecular Imaging of Cancer Cells in Vivo
This technology is a non-invasive method of detecting cancer using in vivo probes that target and bind to receptor cites on or around the cancerous growth.
Applications:
Cancer detection - identify and confirm possible tumors
Optical imaging probe
Advantages:
As an optical imaging probe, there is a high sensitivity for ligand detection and...
Published: 4/3/2023
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Inventor(s): Josef Vagner, Amanda Huynh, Robert Gillies, David Morse
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biomarkers
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