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Novel mRNA-based Prognostic Index Derived from Differential Expression Analysis Improves Overall Survival Estimates in Glioblastoma
This innovation is a set of biomarkers to predict radiotherapy and chemotherapy outcomes in individual Glioblastoma Multiforme patients to better assess their prognosis and therapy. The method uses gene expression analysis to analyze multiple predictive biomarkers and generate a novel Glioblastoma Prognosis Index to accurately predict the overall survival...
Published: 6/13/2023
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Inventor(s): Eric Weterings, Baldassarre Stea, Daruka Mahadevan, Michael Hammer, Christopher Morrison
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios
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Inhibitors of the DNA - KU70/80 Association to Sensitize Cells for Radiation or Chemotherapy
This invention provides methods and compositions for inhibiting cancer cell survival and/or promoting cell death following radiation or chemotherapy applied in cancer treatment. This invention is a second set of Ku70/80 inhibitors that can sensitize cancer cells for chemotherapy. A first set of Ku70/ 80 inhibitors was previously discovered by University...
Published: 7/23/2024
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Inventor(s): Eric Weterings, Daruka Mahadevan, Josef Vagner
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Members of the WNT Signaling Pathway as Predictive Markers and Therapeutic Targets in Glioblastoma Multiforme
This technology is a set of biomarkers to predict radiotherapy and chemotherapy outcomes in individual Glioblastoma Multiforme patients to better assess their prognosis and therapy.
Background:
Glioblastoma Multiforme (GBM) is the most aggressive form of brain cancer and is currently treated through surgical intervention, chemotherapy and radiotherapy....
Published: 4/3/2023
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Inventor(s): Eric Weterings, Baldassarre Stea, Daruka Mahadevan, Christopher Morrison, Michael Hammer
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers
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Small Molecular Weight Inhibitors of the DNA - KU70/80 Association to Sensitize Cells for Radiation or Chemotherapy
This invention provides methods and compositions for inhibiting cancer cell survival and/or promoting cell death following radiation or chemotherapy applied in cancer treatment. Investigators found compounds that may disrupt the Ku70/80 – DNA repair association. The Ku70/80 dimer protein is involved in the repair of radiation-induced DNA double...
Published: 7/23/2024
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Inventor(s): Eric Weterings, Daruka Mahadevan, Josef Vagner
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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