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A Molecular Scaffold for Colonic Drug Delivery
A molecule which passes through the gastrointestinal tract was successfully synthesized and tested for GI MRI imaging in mice. A molecular scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. This contrast agent...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan, Suryakiran Navath, Venkataramana Rao, Rita Marie Woodford, Monica Midura-Kiela, Ahad Ali, Ramesh Alleti
Keywords(s): 5-aminosalicylic acid, gastrointestinal tract, inflammatory bowel disease, pro-drug
Category(s): Technology Classifications > Life Sciences > Diagnostics
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A GI-Specific Contrast Agent for Magnetic Resonance Imaging
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition in this invention. This contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Suryakiran Navath, Venkataramana Rao, Ramesh Alleti, Ahad Ali, Gary Martinez, Robert Gillies, David Morse
Keywords(s): contrast agent, gastrointestinal tract, MRI
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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Targeted Drug Delivery to the Lower GI Tract
This technology is a new, orally administered pro-drug form of 5-aminosalicylic acid (5-ASA) that has been developed and successfully demonstrated. This invention relates generally to the field of medicine, and more specifically to methods and compositions for targeted delivery of substances to the lower GI tract. The invention has particular utility...
Published: 6/20/2024
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Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan
Keywords(s): gastrointestinal tract, inflammation, inflammatory bowel disease, Life Sciences, molecular
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Drug Delivery
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