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A Molecular Scaffold for Colonic Drug Delivery

A molecule which passes through the gastrointestinal tract was successfully synthesized and tested for GI MRI imaging in mice. A molecular scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. This contrast agent...

Published: 3/12/2024 | Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan, Suryakiran Navath, Venkataramana Rao, Rita Marie Woodford, Monica Midura-Kiela, Ahad Ali, Ramesh Alleti

Keywords(s): 5-aminosalicylic acid, gastrointestinal tract, inflammatory bowel disease, pro-drug

Category(s): Technology Classifications > Life Sciences > Diagnostics

Targeted Drug Delivery to the Lower GI Tract

This technology is a new, orally administered pro-drug form of 5-aminosalicylic acid (5-ASA) that has been developed and successfully demonstrated. This invention relates generally to the field of medicine, and more specifically to methods and compositions for targeted delivery of substances to the lower GI tract. The invention has particular utility...

Published: 3/12/2024 | Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan

Keywords(s): gastrointestinal tract, inflammation, inflammatory bowel disease, Life Sciences, molecular

Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Drug Delivery