|
A Molecular Scaffold for Colonic Drug Delivery
A molecule which passes through the gastrointestinal tract was successfully synthesized and tested for GI MRI imaging in mice. A molecular scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. This contrast agent...
Published: 3/12/2024
|
Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan, Suryakiran Navath, Venkataramana Rao, Rita Marie Woodford, Monica Midura-Kiela, Ahad Ali, Ramesh Alleti
Keywords(s): 5-aminosalicylic acid, gastrointestinal tract, inflammatory bowel disease, pro-drug
Category(s): Technology Classifications > Life Sciences > Diagnostics
|
|
Targeted Drug Delivery in the Gastrointestinal Tract, including for Inflammatory Bowel Disease
This invention is a scaffold molecule and a method for using the molecule to deliver active drug molecules to targets in the body. The sucrose-derived scaffold molecule delivers the drug to target sites and releases the drug molecules based on environmental factors, which improves efficacy and reduces side effects.
Background:
Throughout their research,...
Published: 3/12/2024
|
Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics
|
|
Targeted Drug Delivery to the Lower GI Tract
This technology is a new, orally administered pro-drug form of 5-aminosalicylic acid (5-ASA) that has been developed and successfully demonstrated. This invention relates generally to the field of medicine, and more specifically to methods and compositions for targeted delivery of substances to the lower GI tract. The invention has particular utility...
Published: 6/20/2024
|
Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan
Keywords(s): gastrointestinal tract, inflammation, inflammatory bowel disease, Life Sciences, molecular
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Drug Delivery
|
