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C41 Analogs
This invention relates generally to neurodegenerative diseases and conditions, such as Alzheimer’s Disease, characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative...
Published: 9/24/2024
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Inventor(s): Wei Wang, Rui Chang, Vijayan Ramachandran, Patrick Ronaldson
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biologics
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Off-Label Use of an Anti-Hypertensive to Treat Epilepsy
University of Arizona researchers have found the angiotensin II receptor blocker, Candesartan, to effectively reduce epileptic activity.
Background:
As the most prevalent neurological disease, epilepsy is estimated to affect around 50 million people worldwide. In the United States, it is estimated that around 470,000 children and 3 million adults...
Published: 11/14/2024
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Inventor(s): Michael Hammer, Erfan Bahramnejad
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics
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Myelin Breakdown Products as Plasma Biomarkers of Therapeutic Efficacy in the Acute Phase after Stroke
This invention pertains to the use of myelin breakdown products, such as lipids indicative of brain lipid catabolism, as plasma biomarkers for the diagnosis and prognosis of ischemic stroke (IS). Researchers discovered an acute signature of brain lipid catabolism in the plasma 24 hours after a stroke in mouse model research. Notably, a substantial proportion...
Published: 8/12/2024
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Inventor(s): Kristian Doyle, Danielle Becktel
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biomarkers
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Arachidonic Acid Derivatives as Plasma Biomarkers of Chronic Inflammation After Stroke
This invention pertains to the use of arachidonic acid derivatives as plasma indicators for the diagnosis and prognosis of inflammation, including chronic inflammation, following ischemic stroke (IS). Researchers have identified novel plasma biomarkers indicative of neurodegeneration and inflammation in a mouse model of stroke, with particular emphasis...
Published: 8/12/2024
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Inventor(s): Kristian Doyle, Danielle Becktel
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biomarkers
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Diagnostic Tool for Identifying Delirium using Electronic Medical Records
Neurologic, Orientation and Verbal Assessment of Delirium (NOVAD) is a smart-EMR screening tool designed to detect delirium in hospitalized adults. NOVAD leverages assessments that nurses are already familiar with to provide an early warning system for delirium detection, empowering healthcare professionals with actionable insights, leading to timely...
Published: 7/10/2024
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Inventor(s): Nimit Agarwal, Sumit Agarwal
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Medical Devices > Diagnostic
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Novel, Humanized Transgenic Background Mouse Strain for Neurodegenerative Disease Research
This invention is a transgenic mouse model for the study of neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease. This new model crosses a humanized APOE mouse model with a humanized APP gene, both common implicated genetic factors in Alzheimer’s Disease. The technology also developed a Parkinson’s Disease specific...
Published: 6/25/2024
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Inventor(s): Roberta Brinton, Jean Paul Wiegand, Lisa Campbell
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Neurology
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Stroke Outcome Prediction Using Vascular Imaging Features and Machine Learning
This technology is a stroke outcome prediction method to determine patient outcomes and inform treatment decisions. The method utilizes machine learning models trained with patient-specific vascular imaging features, patient demographics, stroke severity scores and clinical history as predictors to forecast a 90-day functional outcome following an ischemic...
Published: 8/1/2024
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Inventor(s): Aditi Deshpande, Kaveh Laksari, Jordan Elliott, Pouya Tahsili-Fahadan
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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Rotational Force-Induced Brain Injury Model
This innovation is a new instrument, model, and treatment for repetitive rotational head trauma in rodents that demonstrates the acute and prolonged pathological, behavioral, and electrophysiological effects of rotational traumatic brain injury (rTBI). Aberrant Cyclin-dependent kinase 5 (Cdk5) activity is a principal mediator of rTBI. Cdk5-enriched...
Published: 6/20/2024
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Inventor(s): James Bibb, Alan Umfress
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Research Tools > Simulators and Modeling Tools, Technology Classifications > Life Sciences > Therapeutics
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Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown...
Published: 7/6/2023
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Inventor(s): Rui Chang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
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Druggable Formulation for Mu/Delta Opioid Antagonist for Enhancing Pain Therapy and Treatment of Opioid Withdrawal
This invention provides compositions and method of pain treatment using a mu/delta opioid receptor heterodimer (MDOR) antagonist which has improved druggability by nanoformulation and/or glycosylation to increase their bioavailability and efficacy. These modified antagonists and formulations provide for enhancement of opioid agonist therapy's antinociceptive...
Published: 3/12/2024
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Inventor(s): John Streicher, Robin Polt, Lajos Szabo, Wafaa Alabsi, Parthasaradhi Reddy Tanguturi
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology
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