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Applications of Deuterated Aldehydes and Isonitriles
This innovation is a novel method of synthesizing calcium channel blockers, with applications to extend the half-life of heart disease medications. This can be used as building blocks to create new pharmaceuticals or potentially used to expand the lifespan of current medications. It has applications to site specific calcium-channel blocking that can...
Published: 6/7/2024
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Inventor(s): Christopher Hulme, Wei Wang, Kevin Schofield, Yueteng Zhang
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Time Resolved Fluorescence based HTS to Detect Structural Changes in cTnI
This innovation involves the development of a probe that attaches to a specific protein called cardiac troponin I (cTnI), which is involved in muscle contraction of the heart. This probe, created through genetic engineering techniques, is designed to detect changes in cTnI's neighboring protein, cardiac troponin T (cTnT). When there's a change...
Published: 5/13/2024
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Inventor(s): Romi Castillo, Jil Tardiff
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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DeScoD-ECG: Deep Score-Based Diffusion Model for ECG Baseline Wander and Noise Removal
The DeScoD-ECG model is a novel electrocardiogram (ECG) baseline wander and noise removal technology that extends the current diffusion model for reconstructing electrocardiogram signals. It establishes a new benchmark in biomedical signal processing to provide a more accurate approximation of ECG signals for detection of cardiovascular irregularities....
Published: 8/23/2024
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Inventor(s): Ao Li, Huayu Li, Gregory Ditzler, Janet Roveda
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Communications & Networking, Technology Classifications > Software & Information Technology > Open Source, Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Diagnostics
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PNA5 Treatment in Myocardial Ischemic Reperfusion Injury Decreases Infarction Size and Promotes Heart Function
This innovation is a novel method of treating cardiovascular disease, specifically, the continued tissue damage that occurs during myocardial ischemic reperfusion injury (MIRI) elicited by myocardial ischemia. While damage during MIRI is multifaceted, this new treatment addresses nearly every caveat including reactive oxygen species (ROS), calcium overload,...
Published: 4/4/2024
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Inventor(s): Meredith Hay, John Konhilas, Christina Hoyer-Kimura, Robin Polt
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Methods of Treating Dilated Cardiomyopathy and Heart Failure
This innovation is the repurposing of drugs used for testosterone-suppression (androgen deprivation) as an innovative strategy to treat heart failure or dilated cardiomyopathy. These drugs are used for treatment of patients with advanced prostate cancer or for adolescents presenting with precocious puberty. This research is supported by published data...
Published: 7/1/2024
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Inventor(s): Guy Reed, Inna Gladysheva, Ryan Sullivan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
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Polymeric Valve for Tricuspid Applications
This invention is a medical implant that is made of polymeric and metallic materials that functions as a replacement valve for tricuspid applications. The valve functions as a flow regulator and can be installed in low pressure, low flow, and low shear cardiovascular structures. It is specifically engineered to reduce stress on the implant structure...
Published: 1/16/2024
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Inventor(s): Marvin Slepian, Danny Bluestein, Brandon Kovarovic
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Medical Devices > Therapeutic
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Heart Valve for Eccentric Orifice
This technology is a novel heart valve and deployment system that maintains eccentric geometries while optimizing valve function and hemodynamics, reducing adverse events. The asymmetrical leaflet design features two identical mirrored larger leaflets and one shorter leaflet. Traditional symmetric leaflet design features three equal leaflets that rely...
Published: 11/16/2023
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Inventor(s): Marvin Slepian, Danny Bluestein, Brandon Kovarovic, Ryan Helbock
Keywords(s):
Category(s): Technology Classifications > Medical Devices > Therapeutic, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Polymeric Heart Valve System and Method of Manufacture
This invention is a new polymer-based heart valve designed to reduce stress on the leaflets of the valve while in use in the human body, providing for longer-term durability compared to other polymer-based valves.
Background:
According to the CDC, heart disease is the leading cause of death in the United States: about one in every four deaths is due...
Published: 11/16/2023
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Inventor(s): Marvin Slepian, Danny Bluestein, Oren Rotman, Brandon Kovarovic
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Medical Devices
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Genetically Engineered Recombinant Proteins for Functional Regenerative Tissue Scaffolds
This technology encompasses the development of recombinant tissue-specific proteins that are used to produce hydrogel scaffolds that mimic the structure of natural tissues and are therefore able to harness the function of the tissues. Each protein sequence is able to be precisely customized, which allows the tissues to be biocompatible and efficient...
Published: 8/1/2024
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Inventor(s): Minkyu Kim, David Knoff
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular
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Interactive Deep Learning for ECG Monitoring
This invention is a deep learning algorithm system that can incorporate human-interpretable explanations in its training process for the analysis of ECG signals. This method takes into account classification loss, the influence of both important and unimportant features to model prediction, and user feedback. This invention is geared toward real-time...
Published: 8/2/2024
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Inventor(s): Chicheng Zhang, Dharma KC, Christopher Gniady, Parth Agarwal
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Software & Information Technology > Health IT
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