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This invention is a biodegradable patch seeded with human neonatal dermal fibroblasts and human-induced pluripotent stem cell-derived cardiomyocytes, which helps regenerate endogenous cardiomyocytes in adult murine, rat and swine models of myocardial infarction as a cause of chronic heart failure (CHF). This invention details changes in specific gene...

Published: 2/3/2025 | Inventor(s): Steven Goldman, Jennifer Koevary, Jordan Lancaster, Jordan Fink, Adrian Grijalva

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Regenerative Medicine / Tissue Engineering, Technology Classifications > Life Sciences > Therapeutics

Clinical ECG Parameters from a Bioengineered Human Cardiac Tissue

This technology consists of a bioengineered cardiac tissue that exhibits electrocardiogram parameters and can be used in screening cardiotoxicity and proarrhythmic potential. Background: Currently, pharmaceutical compounds must be screened for cardiotoxicity using in vitro testing and animal models. However, current cell-based methods rely on cell...

Published: 4/3/2023 | Inventor(s): Ikeotunye Chinyere, Jordan Lancaster, Jennifer Koevary, Steven Goldman

Keywords(s):

Category(s): Technology Classifications > Life Sciences, Technology Classifications > Materials > Biomaterials