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Novel Mechanism-Based Therapy for Aortic Stiffening and Related Cardiovascular and Cerebrovascular Disorders
This invention involves a novel mechanism-based therapy by using a small molecule compound to reduce aging and hypertensive aortic stiffening, subsequently improve blood pressure (BP) control in resistant hypertension patients and prevent or reverse pathologies of vascular cognitive impairment and dementia (VCID) and Alzheimer’s Disease (AD)....
Published: 11/24/2025
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Inventor(s): Hongyu Qiu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Repurposing the FDA-Approved Antibody to Treat Aortic Stiffening and Resistant Hypertension
This innovation repurposes an FDA-approved antibody to treat and prevent aortic stiffening and resistant hypertension (RH). This mechanism-based therapeutic, inhibits receptor mediated inflammatory and pro-stiffness signaling to reduce aortic stiffness and improve blood pressure control, ultimately breaking the root cycle of hypertension.
Background:...
Published: 11/24/2025
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Inventor(s): Hongyu Qiu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Therapeutics
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Pioneering Cell-Based Solutions for Vascular Aging
This invention is a mechanism-based cell therapy for treating aortic stiffening, particularly in cases of old hypertension patients that do not respond to current treatments. It is also intended to help prevent cardiovascular disease and promote healthy aging in older populations.
Background:
Aortic stiffening is a critical age-related risk factor...
Published: 9/15/2025
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Inventor(s): Hongyu Qiu, Liwu Li
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
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