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Scalable Synthesis for Commercial Production of Carbohydrate-Based Molecular Scaffold Compounds for Direct Delivery of Drugs or Nutritional Supplements to the GI Tract
This invention provides a scalable synthesis method for commercial production (kilogram and greater) of novel carbohydrate-based molecular scaffold compounds for various therapeutic and diagnostic applications that have been and are being developed by UArizona inventors. Oral administration and targeted delivery of pro-drugs or other payloads, such...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr.
Keywords(s):
Category(s): Technology Classifications > Materials > Processing, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Nutraceuticals
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Human Colon Polyp Derived Organoid
This innovation is a patient-derived organoid that is used as a screening platform to study both tissues patterning and the kinase pathway dynamics in single cells across many conditions. Through this technology one is able to evaluate the patterning and homeostasis of the cells and tell when they are out of alignment. Through the use of this technology...
Published: 10/4/2023
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Inventor(s): Kelvin Pond, Curtis Thorne, Andrew Paek
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Research Tools > Cell Lines
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High Dimensional Structure-Activity Relationship Approach in Cell-Based Screening for Drug Effects in Intestine
This technology is a high throughput assay utilizing 3D cell culture and multiplex antibody staining techniques to study features of the intestine under various conditions. This technology can be utilized to screen drugs for intestine-related diseases and/or examine drugs for gut toxicity. A complimentary software is then used to measure and analyze...
Published: 4/14/2023
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Inventor(s): Curtis Thorne, Elaheh Alizadeh, Kelvin Pond
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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Design and Synthesis of Pro-Drugs for Selective, Oral Delivery to the Gastrointestinal Tract
This invention provides a method for oral administration and targeted delivery of pro-drugs bonded to a carbohydrate-based molecular scaffold to the gastrointestinal tract, where the pro-drug is released directly in the gastrointestinal (GI) tract by nitroreductase enzymes naturally present. This technology provides a means of delivery of GI therapies...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Pawel Kiela
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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A Molecular Diagnostic Tool for Detecting Clostridium difficile Infection, Carriage and Outbreaks
This invention is an extremely sensitive and precise molecular diagnostic tool to accurately identify clostridium difficile strains.
Background:
Clostridium difficile is a healthcare associated infection with significant patient mortality, morbidity, and may result in prolonged hospital stays. It is the leading cause of healthcare-associated infections...
Published: 4/3/2023
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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Sucrose-Derived Scaffold For Gd MRI Contrast Agent And Method For Use In Colon Cancer Screening
This invention is a targeted molecular imaging agent to be used in conjunction with MRI or CT. It is designed especially for the early and specific detection of colorectal cancer. The formulation of this novel contrast agent allows for non-invasive imaging of the entire colon, with excellent soft-tissue contrast.
Background:
The key to high survival...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Medical Devices > Diagnostic
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Soybean as a Protein Biofactory Platform to Produce Epidermal Growth Hormone
This invention is a soybean capable of producing Epidermal Growth Hormone as a therapeutic agent for a number of applications including reduction of necrotizing enterocolitis (NEC).
Background:
Necrotizing enterocolitis (NEC) is a dangerous condition that occurs in about 10% of premature infants. NEC often requires treatments like surgical removal...
Published: 4/3/2023
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Inventor(s): Eliot Herman, Monica Schmidt, Brad Warner
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Plant Breeds > Plants-GMO, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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Urinalysis Test for a Compromised Gastrointestinal Tract
This technology is an orally administered compound that identifies a compromised gastrointestinal tract, especially in diseases that cause "leaks" in to the blood. If the GI tract is compromised, the compound will be found in the urine and a simple urinalysis can be completed. If the individual is healthy the compound will be expelled in the...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., David Morse
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Life Sciences > Diagnostics
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A GI-Specific Contrast Agent for Magnetic Resonance Imaging
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition in this invention. This contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by...
Published: 3/12/2024
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Inventor(s): Eugene Mash, Jr., Suryakiran Navath, Venkataramana Rao, Ramesh Alleti, Ahad Ali, Gary Martinez, Robert Gillies, David Morse
Keywords(s): contrast agent, gastrointestinal tract, MRI
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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Probiotic Treatment for Clostridium Difficile Infection
This technology is the administration of probiotic bacterial strains with increased expression of a Clostridium difficile attachment protein. These strains, when administered in animal models challenged with high doses of a virulent C. difficile strain prevented death.
Background
Clostridium difficile is the leading cause of healthcare-associated...
Published: 10/29/2024
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan, Michael Mallozzi
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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