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Novel Small Molecule Compounds with Neuroprotective Potential in ALS and Related Neurodegenerative Diseases

This invention comprises a series of novel small molecule compounds developed at the University of Arizona and their method of use for the treatment of locomotor dysfunction associated with Amyotrophic Lateral Sclerosis (ALS) and other diseases associated with proteinopathy of a transactive response (TAR) DNA binding protein, TDP-43. Testing in a previously...

Published: 10/15/2024 | Inventor(s): Daniela Zarnescu, Jon Njardarson, Isaac Chogii, David Smith, Edon Vitaku, Rachel Allen

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics

Novel Small Molecules with Neuroprotective Potential in ALS and Related Neurodegenerative Diseases

This invention is a series of novel small molecule compounds developed at the University of Arizona that may be used in the treatment of Amyotrophic Lateral Sclerosis (ALS), particularly in treating the locomotor dysfunction associated with the disease. The compounds have a neuroprotective effect in that they prevent the aggregation of TDP-43, a neurotoxic...

Published: 9/18/2024 | Inventor(s): Daniela Zarnescu, Jon Njardarson, Isaac Chogii, David Smith, Edon Vitaku, Rachel Allen

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics