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Novel Small Molecule Compounds with Neuroprotective Potential in ALS and Related Neurodegenerative Diseases
This invention comprises a series of novel small molecule compounds developed at the University of Arizona and their method of use for the treatment of locomotor dysfunction associated with Amyotrophic Lateral Sclerosis (ALS) and other diseases associated with proteinopathy of a transactive response (TAR) DNA binding protein, TDP-43. Testing in a previously...
Published: 10/15/2024
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Inventor(s): Daniela Zarnescu, Jon Njardarson, Isaac Chogii, David Smith, Edon Vitaku, Rachel Allen
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics
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Novel Small Molecules with Neuroprotective Potential in ALS and Related Neurodegenerative Diseases
This invention is a series of novel small molecule compounds developed at the University of Arizona that may be used in the treatment of Amyotrophic Lateral Sclerosis (ALS), particularly in treating the locomotor dysfunction associated with the disease. The compounds have a neuroprotective effect in that they prevent the aggregation of TDP-43, a neurotoxic...
Published: 9/18/2024
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Inventor(s): Daniela Zarnescu, Jon Njardarson, Isaac Chogii, David Smith, Edon Vitaku, Rachel Allen
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics
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Annulation to Produce Heterocyclic Compounds
This invention describes a novel way to generate heterocyclic compounds via a 3+2 annulation. This method requires no expensive reagents, and can be done in a chiral manner in some instances.
Background:
Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. The invention possess...
Published: 3/12/2024
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Inventor(s): Jon Njardarson, Isaac Chogii
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Research Tools > Protein, Technology Classifications > Materials > Biocompatible, Technology Classifications > Materials > Chemicals
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Synthesis of Chiral 3-Pyrrolines via an Anionic Annulation Approach
Invention consists of a novel method to access chiral 3-pyrroline products in one step. The treatment of a gamma leaving group with a strong base results in an anion. That anion can then be intercepted by an Ellman type imine. The end result is a robust, reliable, and versatile method to create 3-pyrroline. There are seven main types of anti-hypertensives...
Published: 7/11/2024
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Inventor(s): Jon Njardarson, Isaac Chogii
Keywords(s): biology
Category(s): Technology Classifications > Materials > Chemicals
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