Invention:
This invention describes a novel way to generate heterocyclic compounds via a 3+2 annulation. This method requires no expensive reagents, and can be done in a chiral manner in some instances.
Background:
Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. The invention possess no such drawbacks and is able to create heterocycles in a one pot reaction. These heterocyclic compounds can be used to then synthesize a variety of therapeutically relevant compounds.
Applications:
Can be used to synthesize a variety of drugs conducive to
- Anti HIV compounds
- Anti hypertensive compounds
- Analgesics
- Cancer therapeutics
Advantages:
- Cost effective relative to the existing options
- One pot reaction, allowing for faster turnaround time
- Can generate chiral compounds
