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Engineering of piRNA Generating Synthetic RNAs for Greater Stability and Subcellular Targeting
This invention is for a novel bioinsecticide for use in combatting Bemisia tabaci B mitotype NAF-ME cryptic species, the whitefly pest. This new method utilizes piRNA gene splicing techniques to incite lethal phenotypes into the target with increased targeting and specificity for use in other mechanisms.
Background:
RNAi technology falls under the...
Published: 11/4/2024
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Inventor(s): Judith Brown
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Agriculture & Horticulture > Entomology, Technology Classifications > Life Sciences > RNAi/siRNA
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Virus Inducible Switch
This invention describes a novel platform to control expression of specific plant genes with viruses.
Background:
When many plants are challenged with a viral infection, one of the primary defense mechanisms they have evolved is to deploy the use of plant RNA silencing pathways to control gene expression. Likewise, viruses have co-evolved to evade...
Published: 4/3/2023
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Inventor(s): Judith Brown, Cory Keith, Mark Beilstein
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Research Tools > Reagents
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An Alternative Mode of RNA Interference Triggered through Feeding Synthetic RNAs that are Processed into piRNAs
This invention describes a new method of the widely-used RNA interference technique with potential clinical and research applications.
Background:
RNA interference is a commonly used method to knockdown or “silence” genes. This is typically done using small interfering RNA (siRNA) probes designed with specificity to bind and tag certain...
Published: 5/22/2023
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Inventor(s): Judith Brown, Mosharrof Hossain Mondal, Jorge Rafael Paredes Montero, Alex Flynt
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Therapeutics
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Ultra-High Sensitivity Viral Genome Sequencing
University of Arizona researchers have developed a novel process for rapid genome sequencing of RNA-DNA fragments, even those in archived or damaged biological samples. The process utilizes large panels of primers to amplify short RNA-DNA fragments into separate and off-set pools. These off-set pools of amplicons are used to reconstruct whole and near-whole...
Published: 3/12/2024
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Inventor(s): Michael Worobey, Thomas Watts
Keywords(s): biology
Category(s): Technology Classifications > Life Sciences > RNAi/siRNA
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An Electrokinetic Matrix Management and Polymerase Chain Reaction Device
The following hybrid electrokinetic module allows for sample preparation, PCR, and sensing all on one integrated platform. There are three modules on the platform: the first module isolates targets (cells, bacteria) from high conductivity samples (urine, blood). The second module amplifies nucleic acids through PCR and the third module senses the target.
Applications:...
Published: 8/1/2024
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Inventor(s): Pak Kin Wong, Yi Lu, Tingting Liu, Vincent Gau
Keywords(s): electrokinetics, matrix management, polymerase chain reaction (PCR), thermal cycler
Category(s): Technology Classifications > Engineering & Physical Sciences, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > RNAi/siRNA, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Diagnostic
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