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Universal Chimeric Antigen Receptors for T-Cell Cancer Therapy
This invention is a patient-specific "Universal" Chimeric Antigen Receptor T-cell therapy that uses CAR T cells which target a universal "flag", such as a peptide, protein, or small molecule. The "Universal" CAR T cells are linked to "adapter" molecules or particles which have been designed to bind to patient-specific...
Published: 3/12/2024
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Inventor(s): Michael Worobey
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Custom Chimeric Antigen Receptor (CAR) T-Cell Therapy for Antigen Attack of Cancer Cells
This technology is a new method to develop patient-specific CAR T-cells for conditions characterized by uncontrolled proliferation of T-cells, such as T-cell lymphoma. This approach directs CAR-T cells only to T cells of a given clonal type. There are millions of T cell clones in each patient, each bearing a unique T cell receptor. Here, the inherent...
Published: 6/20/2024
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Inventor(s): Michael Worobey
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Ultra-High Sensitivity Viral Genome Sequencing
University of Arizona researchers have developed a novel process for rapid genome sequencing of RNA-DNA fragments, even those in archived or damaged biological samples. The process utilizes large panels of primers to amplify short RNA-DNA fragments into separate and off-set pools. These off-set pools of amplicons are used to reconstruct whole and near-whole...
Published: 3/12/2024
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Inventor(s): Michael Worobey, Thomas Watts
Keywords(s): biology
Category(s): Technology Classifications > Life Sciences > RNAi/siRNA
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