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Targeting CD44-Moesin Interactions with Small Molecules for Alzheimer’s Disease

This technology is a small molecule compound that could serve as a potential therapeutic for Alzheimer’s Disease (AD). The compound binds to Moesin, a protein that is associated with AD. It targets interactions between Moesin and CD44, an antigen that also has been shown to be a biomarker for AD. Targeting CD44 and Moesin interactions has proved...

Published: 4/3/2023 | Inventor(s): May Khanna, Judith Tello Vega, Haley Williams, Vijay Gokhale, Marcel Patek, Jake Carlson

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Category(s): Technology Classifications > Life Sciences

Allosteric Modulators of TDP-43 for Treating Neurodegenerative Diseases

This invention is a small molecule drug, nTRD22, that can be used to treat currently incurable neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and potentially even Alzheimer’s disease (AD) and Parkinson’s disease (PD). This molecule targets the N-terminal domain (NTD) of the DNA binding...

Published: 4/3/2023 | Inventor(s): May Khanna, Liberty Francois-Moutal, Niloufar Mollasalehi, Vijay Gokhale, David Scott, Judith Tello Vega, Haley Williams

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences