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Rapid, Sensitive Detection of PFOA with Smartphone-Based Flow Rate Analysis utilizing Competitive Molecular Interactions during Capillary Action
This invention pertains to a system of detecting perfluorinated-carbon alkyl chains (PFAs) with a smartphone by analyzing the flow rate. By using a paper-based microfluidic chip, this invention provides rapid detection of PFOAs in a lab. The procedure uses commonly available reagents to flow through a microfluidic chip while also loading it with the...
Published: 2/26/2024
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Inventor(s): Jeong-Yeol Yoon, Lane Breshears, Kelly Reynolds
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Agricultural Engineering, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics
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Sensitive, Low-Cost Detection of SARS-CoV-2 from Clinical Saline Gargle Samples Using Smartphone Fluorescence Microscope
This invention is a method of rapidly detecting SARS-CoV-2 in clinical saline samples using a smartphone fluorescence microscope-based immunofluorescence. This method can detect samples of SARS-CoV-2 in saline gargle solutions down to 10 ag/μl (below single copy level). A saline sample is collected, loaded onto a paper-based microfluidic chip, and...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics
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Direct Capture and Smartphone Quantification of Airborne SARS-CoV-2 on a Paper Microfluidic Chip
This is a rapid, handheld smartphone-based paper microfluidic assay that is capable of directly detecting SARS-CoV-2 in small droplets from the air, without the need for an air sampler or a long collection time. The infected droplets are collected on a paper microfluidic chip, which then has antibody-conjugated submicron fluorescent particle suspension...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Handheld, Rapid, Extremely Sensitive Assay of SARS-CoV-2 Infections
This invention is a rapid antigen test to detect the presence of SARS-CoV-2 that uses a paper microfluidic chip and a smartphone-based fluorescence microscope. Virus-specific antibody-conjugated fluorescent particles and a biological fluid sample (saliva, mouth gargle, etc.) from the patient are added onto a paper microfluidic chip, causing target antigens...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Diagnostics
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Single Copy Level Detection of Virus through Particle Counting on Paper Microfluidics Using Smartphone Based Fluorescence Microscope
University of Arizona inventors have detected norovirus on a microfluidic paper analytic device without using any sample concentration or nucleic acid amplification steps. This technology uses a smartphone-based fluorescence microscope and an image-processing algorithm to isolate the particles aggregated by antibody-antigen binding. This leads to a...
Published: 7/22/2024
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Inventor(s): Jeong-Yeol Yoon, Soo Chung, Kelly Reynolds
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Life Sciences > Diagnostics
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Rapid, Accurate Diagnosis of a Wound Infection with a Smartphone
The technology utilizes a smartphone as a point of care diagnostic to identify species of bacteria in a wound via light scattering.
Background:
The cost for chronic wound care, which is estimated to be $25 billion annually, is mainly due to improper selection of antibiotic treatment and the need to treat an infection quickly. The current method of...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon, Robin Sweeney
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics
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Interfacial Effects Enable Droplet Actuation, Inhibition Relief, and Early Sensing of Polymerase Chain Reaction
This invention is a device and associated methods that improve quantitative real-time polymerase chain reaction (qPCR), especially in point-of-care settings, by allowing detection of PCR amplification and quantification of initial target amount to occur at an earlier amplification cycle. Ultimately this allows for faster results, and thus faster informed...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon, Dustin Harshman
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic
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Extremely Rapid and Fully Reprogrammable Total PCR Assays Using Wire-Guided Droplet Microfluidics
This technology comprises a reprogrammable digital microfluidics assembly, called wire-guided droplet microfluidics, wherein a droplet hangs at the end of a wire or a blunt end syringe needle and moves either over a superhydrophobic surface or within a hydrophobic liquid. The differences in the forces of adhesion to the needle wire and to the superhydrophobic...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon, David You
Keywords(s): digital microfluidics, handheld PCR device, polymerase chain reaction (PCR), wire-guided droplet microfluidics
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diagnostics
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Very Quick Reverse Transcription Polymerase Chain Reaction for Detecting 2009 H1N1 Influenza A Using Wire-Guide Droplet Manipulations
This technology comprises a reprogrammable digital microfluidics assembly, called wire-guided droplet microfluidics, wherein a droplet hangs at the end of a wire or a blunt end syringe needle and moves either over a superhydrophobic surface or within a hydrophobic liquid. The differences in the forces of adhesion to the needle wire and to the superhydrophobic...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon, David You
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Diagnostic
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