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Kappa Opioid Receptor Antagonists for Sleep Disorders
Researchers at UArizona have discovered that kappa opioid receptors influence sleep in mice struggling with chronic pain. In particular they found that a kappa opioid receptor antagonist could be beneficial for improvement of sleep related to pain conditions, as well as other conditions where increased kappa opioid receptor signaling has been observed....
Published: 4/3/2023
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Inventor(s): Frank Porreca, Hisakatsu Ito, Edita Navratilova
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Sleep Disorders, Technology Classifications > Life Sciences > Therapeutics
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Mixed MOR/DOR Agonist Activity Provides Improved Analgesic Efficacy and Tolerability for the Treatment of Pathological Pain States Including Pain-Induced Adaptive Changes in the Nervous System
This invention is the discovery of lead ligands, LYS739 and LYS744, for the treatment of chronic pain including neuropathic pain. These are single compounds representing a novel therapeutic pathway to improve analgesic efficacy.
Background:
Chronic pain is poorly managed with current medications because long term administration or higher doses may...
Published: 4/3/2023
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Inventor(s): Yeon Sun Lee, Victor Hruby, Frank Porreca
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Neurology
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Discovery of a Tetra Peptide with Dual Mu/Delta Opioid Receptor Agonist and Kappa Opioid Receptor Antagonist Properties for the Treatment of Chronic Pain
This invention relates to ligands for mu, delta, and kappa opioid receptors, more particularly to ligands that are agonists for mu and delta opioid receptors, and in some cases ligands that are also antagonists for kappa opioid receptors.
Background:
Opioids are commonly used in the treatment of severe pain. Opioids have analgesic activity through...
Published: 4/3/2023
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Inventor(s): Yeon Sun Lee, Victor Hruby, Frank Porreca
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics
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Discovery of Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor
This invention is a dynorphin analog designed to interact with a receptor that is partly responsible for pain sensations. Dynorphin analog targets the bradykinin receptors instead of the f NMDA receptors. The ligands are novel in the deletion of an arginine residue in position 7 which has been recognized as an essential residue for opioid and non-opioid...
Published: 4/3/2023
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Inventor(s): Yeon Sun Lee, Victor Hruby, Josephine Lai, Frank Porreca
Keywords(s): [des-Arg7]-dynorphin analogs, amphipathic bradykinin receptor, non-opioid effect of dynorphin, pain, pharmacophore
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules
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