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Redox-Directed Chelators Targeting Intracellular Metal Ions
Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, taking advantage of the reducing...
Published: 3/12/2024
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Inventor(s): Elisa Tomat, Tsuhen Chang
Keywords(s): cancer
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules
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Formulaic Imaging for Tissue Diagnosis
This patented system (U.S. Patent 9,952,157) uses a combination of green and blue fluorescence with reflectance, aimed at simple but effective contrast improvements through division, multiplication, subtraction and additions of individual images. To the best of our knowledge no other formulaic images system based on three or more components uses near-UV...
Published: 11/16/2023
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Inventor(s): Urs Utzinger, Bhaskar Banerjee, Timothy Renkoski, Nathaniel Rial, Logan Graves
Keywords(s): autofluorescence, cancer, image contrast optimization, tryptophan
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
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Method for Classification of Cells Based on Gene Expression
Researchers at the University of Arizona have developed methodology to characterize global gene expression within a single cell nucleus. It is envisioned that this technology will be applicable to the diagnosis of disease states in tissue or organ biopsies. It will provide signature expression patterns of normal and diseased tissue. A comprehensive...
Published: 4/3/2023
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Inventor(s): David Galbraith, Georgina Lambert, Roger Lasken, Rashel Grindberg
Keywords(s): cancer, diagnosis, gene expression, nucleus, prognosis
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Diagnostics
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HYD1 Peptides as Anti-Cancer Agents
This invention comprises the composition of HYD1 peptides which are peptides of a specific sequence composed of D amino acids that bind beta integrin and prevent cancer cells from attaching to the extracellular matrix. These peptides are useful as cancer therapeutics on their own. Also, these peptides can be combined with other therapies and be useful...
Published: 4/3/2023
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Inventor(s): Anne Cress
Keywords(s): cancer
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics
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