Invention:
This invention enables the discovery of planetary gases and volatiles for medical gas therapy by using novel gas marbles delivery systems for tissue targeting or systemic and controlled deliveries. Gas and liquid “entrapping” into gel or foam materials have been formulated for various applications including drug delivery. This invention provides an alternative method for “enwrapping” gas and liquid droplets of various concentrations and from a multitude of gases and mixtures thereof originated in a planet atmosphere for a targeted and direct administration in vivo. The invention uses an enwrapping method with nanoparticles to envelop materials with liquid or gases into marbles which can sustain external forces and internal pressures greater than atmospheric pressure without changing shapes. The invention also details an algorithm for discovering planetary gases, a device for high throughput fabrication of these marbles and extraction techniques for accessing planetary gases or isotopes.
Background:
Medical gas therapy has been limited to inhalation delivery to the respiratory systems which have inaccurate dosage and safety issues. Gas entrapping materials (GEM) are formulated from porous materials into foam, gel, or solid matrices. The preparation of these materials requires pressurization and high temperature processing to perfuse gases into the materials pores. Further placement of these marbles into foam or gel can also be used for the preparation of pills or suppositories for oral, vaginal, or rectal administration. The proposed platform is also to be used for investigating various headspace from organic and inorganic materials including profiling atmospheric gases to discover potential biological effects from new gaseous species and mixtures thereof. There are clinical applications of relevance in oncology, neuroscience, gastrointestinal, and other diseases. Modes of therapeutic deliveries can also comprise topical, systemic, ingestive, or other medical interventions known in the prior art.
Applications:
- Formulation method for drug delivery
- Medical gas therapy
- Oncology
- Neuroscience
- Gastrointestinal
- Other diseases
- Multiple modes of delivery/administration
- Topical
- Systemic
- Ingestive
Advantages:
- Versatility
- Readily available natural gases
- Maintains shape
