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There are two cysteine proteases that are encoded by SARS-CoV-2, the main protease (Mpro) and the papain-like protease (PLpro). Both of these proteases have been shown to be essential in viral replication and are validated antiviral drug targets. PLpro cleaves the viral SARS-CoV-2 polyprotein at three sites. In addition, it modulates host immune response...

Published: 7/26/2024 | Inventor(s): Jun Wang, Chunlong Ma, Naoya Kitamura, Yanmei Hu

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Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Small Molecules

Broad-Spectrum Antivirals Against Enterovirus D68, A71, and Coxsackievirus B3

This invention is a set of compounds which have antiviral activity against the enteroviruses D68, A71, and coxsackievirus B3. They can be used both prophylactically, to prevent infection, and therapeutically, to treat it. Background: Enteroviruses are a group of viruses that belong to the Picornaviridae family. One enterovirus, the polio virus,...

Published: 11/16/2023 | Inventor(s): Jun Wang, Rami Musharrafieh, Chunlong Ma, Jiantao Zhang, Yanmei Hu

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Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics