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Small Molecule Chaperones of CLN1 and CLN2
The inventors here have identified a method of treating Batten Disease with small molecules that target palmitoyl-protein thioesterase 1 (PPT1), tripeptidyl peptidase 1 (TPP1), enzymes that are deficient and less active in Batten disease or Neuronal Ceroid Lipofuscinosis. The CLN1 and CLN2 genes regulate the production of these enzymes, respectively.
Background:
Batten...
Published: 7/12/2023
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Inventor(s): May Khanna, Lipsa Jena
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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