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Inhibition of SGK1 via a Synthetic Protein-Protein Interaction Inhibitory Peptide
This technology is a peptide that binds serum glucocorticoid kinase 1 (SGK1) to prevent binding to glucocorticoid-inducible leucine zipper protein (GILZ). The interaction between GILZ-SGK1 protects SGK1 from degradation, and the peptide developed prevents this interaction allowing for SGK1 degradation and decreased SGK1-mediated cardiac hypertrophy,...
Published: 6/6/2024
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Inventor(s): Erik Blackwood, Christopher Glembotski
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences
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