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Rapid, Sensitive Detection of PFOA with Smartphone-Based Flow Rate Analysis utilizing Competitive Molecular Interactions during Capillary Action
This invention pertains to a system of detecting perfluorinated-carbon alkyl chains (PFAs) with a smartphone by analyzing the flow rate. By using a paper-based microfluidic chip, this invention provides rapid detection of PFOAs in a lab. The procedure uses commonly available reagents to flow through a microfluidic chip while also loading it with the...
Published: 2/26/2024
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Inventor(s): Jeong-Yeol Yoon, Lane Breshears, Kelly Reynolds
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture > Agricultural Engineering, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics
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Surface-Modified Electrospray Needles for Mass Spectrometry
With this invention, electrospray needles used in mass spectrometry are coated to prevent sticking and clogging of analytes, resulting in improved mass detection sensitivity and consistency of analysis. The coating comprises an organic material covalently bonded to an interior surface of the electrospray needle. The coating is electrically non-conductive...
Published: 3/12/2024
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Inventor(s): Michael Marty, Craig Aspinwall, Marius Kostelic, Chih-Chieh Hsieh
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Mass Spectrometry, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Materials > Coatings
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Printed Wearable Microfluidic Sweat Sensor Array
This invention is a wearable biosensor that is capable of sensing biomarkers of interests in sweat. This invention has the flexibility to be worn, the durability to withstand the common degradation of polymers in complex aqueous/organic environments, and the sensitivity to pick up on multiple biomarkers found in human eccrine sweat.
Background:
Wearable...
Published: 3/12/2024
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Inventor(s): Erin Ratcliff, Jonathan Harris
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Communications & Networking > Networking, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Medical Devices > Diagnostic
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Single Copy Level Detection of Virus through Particle Counting on Paper Microfluidics Using Smartphone Based Fluorescence Microscope
University of Arizona inventors have detected norovirus on a microfluidic paper analytic device without using any sample concentration or nucleic acid amplification steps. This technology uses a smartphone-based fluorescence microscope and an image-processing algorithm to isolate the particles aggregated by antibody-antigen binding. This leads to a...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon, Soo Chung, Kelly Reynolds
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Life Sciences > Diagnostics
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Packed Bed Scintillation Particles for Radioisotope Detection and Separations
University of Arizona researchers have developed hydrophilic scintillation microparticles made with polystyrene cores, doped with a scintillator material, and encapsulated with a thin silica coating. The resulting microparticles are hydrophilic and can be easily surface modified to provide a variety of purposes in radioisotope activity detection, such...
Published: 3/12/2024
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Inventor(s): Craig Aspinwall, Minhui Han, Colleen Janczak
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Nanomaterials, Technology Classifications > Research Tools > Protein, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Sensors & Controls > Particle & Radiation
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Methods For Building A Self-Contained Responsive Biological System
This technology is a new organ modeling system that utilizes plant leaves to study cancer mechanism and drug interactions. It focuses on the optimized scaffolding of decellularized plant tissues seeded with mammalian cells. The model is ideal for producing a 3D vascularized biological system that can be dynamically controlled through changes in perfusion...
Published: 11/16/2023
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Inventor(s): Jerome Lacombe, Ashlee Harris, Ryan Zenhausern, Frederic Zenhausern
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Research Tools
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Enhanced Microfluidics PDMS Pneumatic Valve
This invention significantly improves the resistance of pneumatic valves in microfluidic arrays to >500 GΩ (an order of magnitude improvement) with fast opening and reasonable closing times as well as good stability. The result is greatly improved signal-to-noise ratio (SNR) resulting in higher analytical throughput at lower cost.
Background:...
Published: 3/12/2024
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Inventor(s): Xuemin Wang, Christopher Baker, Craig Aspinwall
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics
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A Microfluidic System for Automated Dissociation of Tissue
This invention is an automated system with the ability to dissociate a variety of soft biological tissues, such as those found in the heart or central nervous system, into viable single cells for culture preparation and other various uses. It includes a microfluidic device made from clear, low-cost, biocompatible materials integrated with imaging and...
Published: 2/1/2024
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Inventor(s): Yitshak Zohar, Linda Restifo, Linan Jiang
Keywords(s): automation, drug discovery, flow shear, high throughput screening (HTS), microfluidics, primary neuron culture, tissue dissociation, viability
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Research Tools > Screening assays
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