http://arizona.technologypublisher.comBe the first to know about the latest inventions and technologies available from The University of Arizonaen-USThu, 29 Jul 2010 13:22:22 GMTWed, 07 Jul 2010 17:02:30 GMThttp://blogs.law.harvard.edu/tech/rssldemasque@ott.arizona.eduCopyright 2010, University of Arizonahttp://arizona.technologypublisher.com/technology/5396Wed, 07 Jul 2010 17:02:30 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5396http://arizona.technologypublisher.com/technology/5395Chip Based, Dual Beam Refractometer Provides a Compact, Refractive Index Measurement Platform of Unprecedented Sensitivity and Robustness Refractive index sensor platforms have demonstrated a high level of sensitivity; however instrumentation typically requires optical alignment, resulting in instruments that are fragile, expensive, and often confined to a laboratory work bench. A University of Arizona Chip Based, Dual Beam Refractometer integrates organic LEDs and organic PV cells into a planar chip that demonstrates superior detection limits at faster rates without mechanical alignme...Wed, 07 Jul 2010 16:59:38 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5395http://arizona.technologypublisher.com/technology/5293Background: The development of commercial Ion Mobility Spectrometer (IMS) devices has enabled rapid identification of explosives and explosive residues, chemical agents, airborne toxins, and other volatile substances. Despite the transformation that has occured in the ion mobility spectrometry in recent years, the full potential of the technique has not been realized, particularly in the analysis of gases. This is due to the low numbers of ions generated in the small ionizers employed in conventional ion mobility spectometers. Existing devices are limited in detecting traces of materia...Fri, 04 Jun 2010 16:10:39 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5293http://arizona.technologypublisher.com/technology/5292Fri, 04 Jun 2010 16:10:39 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5292http://arizona.technologypublisher.com/technology/5284Thu, 03 Jun 2010 16:05:27 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5284http://arizona.technologypublisher.com/technology/5269Tue, 25 May 2010 15:27:27 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5269http://arizona.technologypublisher.com/technology/5268Background: Urban environments are notorious for poor performance of wireless communications systems. This is because RF propagation between a transmitter and a receiver in an urban environment is often impaired by manmade structures, e.g. buildings and other structures comprising the environment. If there is no direct line of sight between the transmitter and receiver, which is often the case, the signal is propagated via multiple propagation paths through the network of space between the buildings, i.e. through streets, alleys, etc. due to reflections from the building walls. Since d...Mon, 24 May 2010 14:19:45 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5268http://arizona.technologypublisher.com/technology/5267Mon, 24 May 2010 13:21:34 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5267http://arizona.technologypublisher.com/technology/5229FIELD OF THE INVENTION This invention relates to the cloning and expression of the human EP.sub.3 prostaglandin receptor. Methods of identifying compounds capable of both binding to and activating the human EP.sub.3 receptor are also disclosed. BACKGROUND OF THE INVENTION Prostaglandins are a group of lipid-soluble hormone mediators derived from the metabolism of arachidonic acid via the cyclooxygenase enzymatic pathway. In the prostaglandin biosynthetic pathway, arachidonic acid is first converted to the endoperoxide PGH2 by PGH2 synthases followed by the cell-specific isomerization or...Tue, 18 May 2010 11:34:31 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5229http://arizona.technologypublisher.com/technology/5165Mon, 10 May 2010 11:18:28 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5165http://arizona.technologypublisher.com/technology/5162Fri, 07 May 2010 16:47:29 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5162http://arizona.technologypublisher.com/technology/5146Background: Phthalocyanines are a versatile class of p-conjugated organic semiconductors applicable as materials in several electronic devices such as organic xerographic protoreceptors, nonlinear optical components, field-effect transistors, organic light-emitting diodes, and solar cells (i.e. organic electronics). Titanyl Phthalocyanine (TiOPc) is a known photoconductor and solid state IR absorber. Absorption of light in thin-films of organic semi-conductors is one of the four major processes - light absorption, exciton migration, charge separation, charge collection - that are esse...Fri, 07 May 2010 12:16:09 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5146http://arizona.technologypublisher.com/technology/5144Fri, 07 May 2010 10:47:48 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5144http://arizona.technologypublisher.com/technology/5114Fire Damper for Flammable Storage Cabinets Reduces Ventilation Cost and Improves Safety BackgroundFlammable storage cabinets (FSC) are constructed to store volatile chemicals and solvents used in the laboratory setting. FSCs typically come with capped ports that allow for exhaust ventilation. Ventilation and potential fire containment are two issues that frequently must be balanced in the design of a FSC system. When ventilation is required, expensive steel pipes are typically run from the lower side port to the exhaust system. The high melting point of the pipes helps to ensures that ...Tue, 04 May 2010 16:03:10 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/5114http://arizona.technologypublisher.com/technology/4992Tue, 27 Apr 2010 07:42:37 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4992http://arizona.technologypublisher.com/technology/4991Tue, 27 Apr 2010 07:36:40 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4991http://arizona.technologypublisher.com/technology/4976Fri, 16 Apr 2010 11:10:22 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4976http://arizona.technologypublisher.com/technology/4975Fri, 16 Apr 2010 11:08:46 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4975http://arizona.technologypublisher.com/technology/4974Fri, 16 Apr 2010 11:08:45 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4974http://arizona.technologypublisher.com/technology/4880Thu, 01 Apr 2010 13:59:14 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4880http://arizona.technologypublisher.com/technology/4879Thu, 01 Apr 2010 13:59:14 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4879http://arizona.technologypublisher.com/technology/4878Background: Human pulmonary tuberculosis is caused by a bacterial agent called Mycobacterium tuberculosis. Almost one third of the world's population suffers from tuberculosis of which nearly three million people die yearly. This disease is the single largest infectious cause of mortality in the world. Currently, diagnosis for TB requires acid fast staining for the presence of bacteria in sputum followed by a culture of the bacteria. However, the sensitivity of the sputum smear is only around 50%, and the culturing process can last from 3 to 8 weeks. This necessitates the development o...Thu, 01 Apr 2010 13:34:20 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4878http://arizona.technologypublisher.com/technology/4877Basis of Invention: University of Arizona researchers have developed a non-surgical technique by which proteins targeted to specific cell layers in the eye cause changes in cell:cell interactions such that the membrane becomes more permeable to fluid, allowing the eye to drain naturally. This will prevent the increases in ocular pressure which result in blindness. Current treatments for Glaucoma offer only a temporary solution: pharmacological treatments are ineffective in the long-term and have multiple side effects, laser treatments only solve the problem for a limited period and can ...Thu, 01 Apr 2010 13:21:02 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4877http://arizona.technologypublisher.com/technology/4874Basis of the Invention: University of Arizona researchers have found a novel protein from Mycobacterium tuberculosis which forms pili. Pili are well known in other bacteria, where they mediate cell:cell adhesion and virulence, specifically affecting bacterial:host cell interactions. They have not previously been identified in M. tuberculosis. Mtp (M. tuberculosis pili) bind to the laminin in the lung which allows the bacterium to adhere to the pulmonary lining. Mtp therefore play a pivotal role in adherence and colonization of the lung. Mtp is antigenic and causes a host immune reaction...Wed, 31 Mar 2010 14:19:02 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4874http://arizona.technologypublisher.com/technology/4584Wed, 10 Feb 2010 11:51:42 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4584http://arizona.technologypublisher.com/technology/4552Mon, 08 Feb 2010 14:34:13 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4552http://arizona.technologypublisher.com/technology/4545Fri, 05 Feb 2010 08:52:14 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/4545http://arizona.technologypublisher.com/technology/3562Thu, 05 Nov 2009 07:51:35 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3562http://arizona.technologypublisher.com/technology/3557Tue, 03 Nov 2009 10:08:55 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3557http://arizona.technologypublisher.com/technology/3556Mon, 02 Nov 2009 12:14:25 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3556http://arizona.technologypublisher.com/technology/3474Background: Diffuse Large B Cell Lymphoma (DLBCL), which accounts for 35% of all cases of lymphoma, is a heterogeneous disease with variable patient survival. Gene expression profiling studies of DLBCL, performed by four different research groups (Rosenwald, et al, 2002; Tome, et al, 2005; Shipp et al, 2002; Lossos, et al, 2004) have identified largely non-overlapping gene sets associated with patient survival. No side-by-side studies have been published to date. These conflicting data make it difficult to determine which genes have prognostic significance. For example, one study found...Tue, 29 Sep 2009 11:57:02 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3474http://arizona.technologypublisher.com/technology/3473Background: Many mutations and drug compounds affect neural function by altering the shape and density of neuron networks, changes that can easily be seen by analyzing still images of prepared neuron cultures that have been genetically altered or exposed to experimental compounds. Drug discovery for developmental brain disorders lags decades behind that in other conditions, however, largely because existing cell-based screening assays are laborious to analyze accurately. A new software application, NeuronMetrics, can greatly improve the speed and accuracy of neuron-culture image analys...Tue, 29 Sep 2009 11:57:01 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3473http://arizona.technologypublisher.com/technology/3472Background: Immunoassays are used widely for detecting substances due to the specificity and ease of using antibodies. These properties have lead to immunoassay application in a variety of diverse industries including as clinical diagnosis, food contamination, environmental surveying, basic scientific research, and drug discovery. Numerous improvements have been made to make antibody based detection more sensitive (ELISA, RIA, and the like) but sensitivity and detection of the antigen-antibody interaction limit utility. Also, current immunoassays have not been adapted to microscale suc...Tue, 29 Sep 2009 11:57:01 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3472http://arizona.technologypublisher.com/technology/3471Tue, 29 Sep 2009 11:57:01 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3471http://arizona.technologypublisher.com/technology/3470Background: The field of information and computer technology is reaching a strategic inflection point, where a number of changes need to come together at the same time. One of these changes is the eventual end of the exponential growth of chip density, and the other is of high availability, fault-tolerance, and maintainability of information computing technology systems. We envision a scientific and technological revolution in the field of computer and information technology through a synergistic multidisciplinary research and training approach that will combine computer engineering an...Tue, 29 Sep 2009 11:57:00 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3470http://arizona.technologypublisher.com/technology/3462Fri, 25 Sep 2009 14:29:07 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3462http://arizona.technologypublisher.com/technology/3457Fri, 25 Sep 2009 10:41:54 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3457http://arizona.technologypublisher.com/technology/3434Background: The current knowledge of the pathogenesis and potential immunity for necrotic enteritis is greatly limited by the lack of a reliable experimental model. Current models are based upon the spontaneous occurrence of the disease as a result of feeding patterns or various methods of experimental inoculation with Clostridium perfringens yielding a low rate of lesion formation. In fact, most of these models fail to produce detectable lesions of necrotic enteritis greatly hampering the collection of data. The creation of a reliable animal model for necrotic enteritis would enable r...Tue, 15 Sep 2009 15:30:03 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3434http://arizona.technologypublisher.com/technology/3433Background: Small, unmethylated stretches of DNA called CpG islands, made up of cytosine and guanine repeats, are located next to housekeeping genes essential for cellular function. These, when positioned next to the promoter region of tumor suppression genes, can become abnormally methylated resulting in the formation of cancerous cells. Identification of these methylated CpG islands will aid in the diagnosis of human carcinomas. Applications:*Identifies specific DNA sequences containing subtle chemical modifications*Can be used for medical diagnosic purposes in various forms of cance...Tue, 15 Sep 2009 15:30:03 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3433http://arizona.technologypublisher.com/technology/3431Tue, 15 Sep 2009 15:30:03 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3431http://arizona.technologypublisher.com/technology/3430Background: Clostridium difficile-associated disease (CDAD) is of importance to humans, and is also a major cause of neonatal enteritis in pigs. Antimicrobials disrupt the normal flora of the colon allowing ingested spores to germinate freely. Piglets 1 to 7 days of age are infected resulting with gross lesions, mesocolonic edema and constipation. A recent study concluded that nearly one third of piglets with enteritis have been infected with C. difficile. This, combined with the importance of CDAD in humans, has brought about the need for a detailed examination of the organism includi...Tue, 15 Sep 2009 15:30:02 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3430http://arizona.technologypublisher.com/technology/3429 Background: Turmeric, the powdered rhizome of the herb Curcuma longa L. (Zingiberaceae), has been used in Ayurvedic medicine for over 4000 years to treat inflammation, skin wounds and tumors. Turmeric extracts have been reported to have antimicrobial, anti-inflammatory, antioxidant, and anticancer effects. Powdered turmeric, or its extract, is now found in numerous commercially available botanical supplements. The best characterized of the compounds found in turmeric is curcumin, which has been shown to reduce inflammation. While the sites of action and activity of curcumin have been ...Tue, 15 Sep 2009 15:30:01 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3429http://arizona.technologypublisher.com/technology/3423Fri, 11 Sep 2009 09:48:57 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3423http://arizona.technologypublisher.com/technology/3422Fri, 11 Sep 2009 09:48:56 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3422http://arizona.technologypublisher.com/technology/3413Thu, 10 Sep 2009 10:18:39 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3413http://arizona.technologypublisher.com/technology/3412Thu, 10 Sep 2009 08:42:17 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3412http://arizona.technologypublisher.com/technology/3411Tue, 08 Sep 2009 13:06:20 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3411http://arizona.technologypublisher.com/technology/3410Tue, 08 Sep 2009 13:06:20 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3410http://arizona.technologypublisher.com/technology/3394Mon, 31 Aug 2009 12:42:14 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3394http://arizona.technologypublisher.com/technology/3385Fri, 28 Aug 2009 07:11:14 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3385http://arizona.technologypublisher.com/technology/3384Background: Confocal microscopy and Optical Coherent Tomography (OCT) are both promising modalities for in vivo optical imaging, for diagnosis, biopsy and other medical analysis. One of the strengths of OCT is its ability to image deeper into tissue as it employs near infrared light and the coherence gating provides higher dynamic range for detection of weak signal. On the other hand, OCT is limited in resolving cellular details and does not work in fluorescence, thus limiting the type of contrast agents that can be used for targeting disease. Scanning confocal microscopes provide high...Fri, 28 Aug 2009 07:11:13 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3384http://arizona.technologypublisher.com/technology/3383Background: Conventional diffractive lenses have a series of concentric rings with discrete steps in their profile. In general, the spacing between those steps gets progressively closer together from the center of the lens towards the edge. Bifocal diffractive lenses use this type of design to provide two different focal lengths, but this is not efficient, as 40% of the incident light is transmitted to the 0th diffractive order, corresponding to distance vision and 40% is transmitted to the +1st diffractive order, which corresponds to near vision. The remaining 20% is sent to unused dif...Fri, 28 Aug 2009 07:11:13 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3383http://arizona.technologypublisher.com/technology/3382Fri, 28 Aug 2009 07:11:13 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3382http://arizona.technologypublisher.com/technology/3379Thu, 27 Aug 2009 16:39:45 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3379http://arizona.technologypublisher.com/technology/3378Thu, 27 Aug 2009 16:07:02 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3378http://arizona.technologypublisher.com/technology/3363Background: Rapid tissue proliferation in cancer results in a number of adaptive cellular responses, primarily the distinct but related processes of angiogenesis and glycolysis. Angiogenesis - the formation of new vasculature - accelerates tumor growth and provides a gateway to metastasis via the new blood vessels. As tumor cells multiply and are forced farther away from the blood supply, the ensuing hypoxia results in a switch to an anaerobic metabolism. This metabolic switch selects for cells with upregulated glycolysis, thus initiating a cascade that results in enhanced glycolytic f...Wed, 26 Aug 2009 13:59:15 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3363http://arizona.technologypublisher.com/technology/3335Background: Drug design and development is an enormously expensive and time consuming process. Only a tiny fraction of the compounds that are screened in the discovery phase will ever reach the market. Part of the reason for this rate of attrition is that the ADME (absorption, distribution, metabolism and excretion) profile of drug candidates are tested on animals at the end of the lead optimization phase. At this point a relatively large amount of capital has already been invested in each drug candidate, many of which will be abandoned due to unfavorable ADME properties. The animal st...Wed, 19 Aug 2009 13:01:47 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3335http://arizona.technologypublisher.com/technology/3202Tue, 21 Jul 2009 09:09:38 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3202http://arizona.technologypublisher.com/technology/3201Mon, 20 Jul 2009 16:55:51 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3201http://arizona.technologypublisher.com/technology/3183Mon, 20 Jul 2009 12:34:36 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3183http://arizona.technologypublisher.com/technology/3182Mon, 20 Jul 2009 12:11:00 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3182http://arizona.technologypublisher.com/technology/3181Mon, 20 Jul 2009 11:46:14 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3181http://arizona.technologypublisher.com/technology/3178Mon, 20 Jul 2009 10:06:48 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3178http://arizona.technologypublisher.com/technology/3177Mon, 20 Jul 2009 06:51:05 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3177http://arizona.technologypublisher.com/technology/3175Mon, 20 Jul 2009 06:51:04 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3175http://arizona.technologypublisher.com/technology/3174Mon, 20 Jul 2009 06:51:03 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3174http://arizona.technologypublisher.com/technology/3173Mon, 20 Jul 2009 06:51:03 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3173http://arizona.technologypublisher.com/technology/3171Background: With the increase in attention to security concerns over past few years, ion mobility spectrometers have become popular devices for rapid detection and identification of airborne toxins, volatile organics, explosives, and other materials. However, a drawback to these devices is the sensitivity with which they can measure these compounds. The lack of sensitivity of ion mobility spectrometers can be attributed in part to the current shutter designs. An increase in the sensitivity can be realized through the use of the compressing ion-beam shutters described in this invention....Fri, 17 Jul 2009 12:03:00 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3171http://arizona.technologypublisher.com/technology/3153Background: University of Arizona researchers have developed a new technology for measuring the properties of molecules and/or thin films at surfaces and interfaces. It can be used for measuring structural and mass changes in films deposited on the resonator surface: specifically lipid membranes, lipid membrane/protein interfaces and interfaces between membrane proteins and soluble proteins. It will be useful in surface plasmon based spectrometers and biosensors, as well as in other optical measurement techniques which use surface phenomena. It measures both reflected and transmitted l...Tue, 07 Jul 2009 06:40:24 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3153http://arizona.technologypublisher.com/technology/3147Background: AzCam is a software package and data acquisition architecture developed at the University of Arizona Imaging Technology Laboratory (ITL) as a control interface for scientific and industrial image acquisition hardware. Specifically designed for use at astronomical observatories, university labs, and companies with a wide range of cameras, detector configurations, and imaging characterization requirements, AzCam creates a common user interface and software toolset for both CCD and CMOS cameras.While most data acquisition systems are specific to a particular hardware system, A...Thu, 02 Jul 2009 14:48:57 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3147http://arizona.technologypublisher.com/technology/3146Background: Optical data storage systems require a great deal of sophistication in their design and analysis. It is often necessary to simulate portions of the optical system with ray tracing or diffraction modeling. This technology introduces new computer software called OptiScan that operates in the MATLAB™ language environment. OptiScan combines many of the routines developed at The University of Arizona College of Optical Sciences over the last several years for modeling optical data storage systems and other applications, as well as some new capabilities. The motivation for devel...Thu, 02 Jul 2009 14:48:56 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3146http://arizona.technologypublisher.com/technology/3143Thu, 02 Jul 2009 13:12:14 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3143http://arizona.technologypublisher.com/technology/3142Thu, 02 Jul 2009 13:12:13 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3142http://arizona.technologypublisher.com/technology/3119Technology: Infectious viral clones in the form of plasmid vectors are used in experimental inoculation of plants to identify resistant varieties. The varieties listed below may be purchased from the University of Arizona. List of additional varieties and references for all viruses are available upon request. Partial list of available varieties:1. Bean calico mosaic virus2. Chino del tomate virus 3. Cotton leaf crumple virus (developed with North Carolina State University) 4. Cotton leaf Curl Gezira virus and satellite DNA5. Cucurbit leaf curl virus-AZ6. Macroptilium mosaic Puerto Ric...Tue, 30 Jun 2009 06:55:08 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3119http://arizona.technologypublisher.com/technology/3112Background: A common difficulty in targeting drug delivery to the brain is the inability of large chemical compounds to cross the blood brain barrier. Inventors have devised a helical glycopeptide carrier molecule with the ability to traverse the blood brain barrier enabling its use in a variety of pharmaceuticals. While 50% of alpha helices are known to be amphipathic and therefore potential transporters, the molecule must also retain a membrane bound conformation to promote endocytosis as well as a water-soluble conformation to facilitate exit from the membrane. Applications:*Target...Thu, 25 Jun 2009 13:51:47 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3112http://arizona.technologypublisher.com/technology/3111Background: Zinc finger proteins, the most abundant and diverse binding motifs, recognize a wide range of nucleic acid targets. Each zinc finger domain can recognize a 3-base tract, thus a 3-finger protein can recognize a tract of 9 base pairs with high affinity. With this technology, University of Arizona researchers have generated novel constructs of zinc finger binding protein modules with reporters such as protein complementation assays (PCA) to detect specific nucleic acid sites of interest. Applications:*Recognition of specific nucleic acid sequences unique to pathogens*Detection...Thu, 25 Jun 2009 12:57:07 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3111http://arizona.technologypublisher.com/technology/3108Background: Glaucoma is a leading cause of blindness that affects about 2.2 million in the US alone. Approximately one-half to two-thirds of all glaucoma cases are associated with increased intraocular pressure (IOP). Bestrophin proteins are believed to function as chloride channels and/or as modifiers of calcium response in cells. These two functions are critical to the water transport function of the ciliary body, which generates aqueous flow in the eye and thus IOP. Best2 has been shown to be expressed in mouse in the non-pigmented epithelium of the ciliary body in the eye. Based on...Thu, 25 Jun 2009 12:01:48 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3108http://arizona.technologypublisher.com/technology/3107Background: Since their discovery in the early 1970's, endogenous opioid peptides have been researched for their applicability as analgesics and as a replacement for naturally occurring alkaloids such as morphine or codeine. However, one of the difficulties in deveoping opioid peptides for use as pharmaceuticals is their inability to penetrate the blood brain barrier (BBB). This barrier enables transport of compounds necessary for proper brain function while preventing unwanted substances from entering. Optimization of opioid peptides for transport across the blood brain barrier would ...Thu, 25 Jun 2009 12:01:47 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3107http://arizona.technologypublisher.com/technology/3106Background: Both opioid agonists and substance P antagonists play a vital role in the neuropathic pain state. Co-administration of an opioid agonist and a substance P antagonist has shown antinociceptive potency in acute pain states. Furthermore, the co-administration of these compounds has shown a decrease in overall opioid induced tolerance in chronic trials. This suggests that the action of the opioid agonist is closely linked to that of substance P rather than each operating independently of one another. Applications:*Development of bifunctional peptides that incorporate both the o...Thu, 25 Jun 2009 12:01:47 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3106http://arizona.technologypublisher.com/technology/3092Background: Non-diffracting and "self-healing" Bessel beams have attracted great interest because of their invariant propagation properties. Bessel beams play an important role in optical acceleration, particle guiding and manipulation, imaging, microfabrication, nonlinear optics, and lithography. In comparison to Gaussian beams, Bessel beams do not diverge with propagation and maintain higher power for longer propagation distances. The conventional techniques for generating them require bulk optics, free space elements or careful alignment. Although there are some efforts in compact g...Wed, 24 Jun 2009 15:29:55 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3092http://arizona.technologypublisher.com/technology/3091Wed, 24 Jun 2009 14:44:39 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3091http://arizona.technologypublisher.com/technology/3080Tue, 23 Jun 2009 12:19:37 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/3080http://arizona.technologypublisher.com/technology/2758Tue, 16 Jun 2009 11:02:18 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2758http://arizona.technologypublisher.com/technology/2730Background: Terahertz (THz) signals can be used in numerous fields such as medical imaging where they provide a safe alternative to the use of x-rays, security imaging where THz waves can safely be used to detect and identify dangerous or illegal materials, and radiotelescopy where scientists can use THz waves to peer deep within molecular clouds to study star formation. Other proposed uses of THz technologies are in manufacturing where they can be used to see through plastic and cardboard packaging to perform quality control measures and in high altitude communications allowing satelli...Thu, 11 Jun 2009 14:46:16 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2730http://arizona.technologypublisher.com/technology/2729Thu, 11 Jun 2009 14:46:15 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2729http://arizona.technologypublisher.com/technology/2728Thu, 11 Jun 2009 14:46:13 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2728http://arizona.technologypublisher.com/technology/2727Background: Law students, recent law graduates, and judicial clerks seeking government internships or post-graduate honors programs are confronted with the time-consuming task of determining what federal, state, or local government departments offer such programs, what specific opportunities are available, and what the application criteria are. Although this information is publicly available, it is dispersed throughout the various governmental departments that offer these programs. What most applicants desire is a single, current, comprehensive source of all the available programs. Thi...Thu, 11 Jun 2009 14:46:12 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2727http://arizona.technologypublisher.com/technology/2724Thu, 11 Jun 2009 10:34:03 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2724http://arizona.technologypublisher.com/technology/2339Background: Many tumors that initially respond to chemotherapy treatments later recur, often with multi-drug resistant phenotype, due to the treatment’s failure to eliminate minimal residual disease. These tumor cells’survival can be accounted for in part by de novo drug resistance. This mechanism by definition does not require selection by any particular drug and is instead more concerned with the tumor microenvironment. Specifically the inventors have shown that de novo drug resistance in leukemia cells is associated with attachment to the extracellular matrix protein fibronectin thr...Thu, 21 May 2009 13:43:49 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2339http://arizona.technologypublisher.com/technology/2335Title: CHO-K1 Cell Lines Expressing Prostanoid Receptors Basis of Invention: University of Arizona researchers have created chinese hamster ovary cells expressing the human EP3A, EP3D, EP3E and EP3F prostanoid receptors. These G-coupled receptors are widely found in smooth muscle such as the gastrointestinal tract and in bronchial tissue. They are proposed to mediate contractile activity of the smooth muscle. As such, the new cell lines are expected to be a useful research tool for investigating receptor activity: they can be used in functional studies of receptor activation and seco...Thu, 21 May 2009 13:17:29 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2335http://arizona.technologypublisher.com/technology/2334Title: HEK Cell Lines Expressing Prostanoid Receptors Basis of Invention: University of Arizona researchers have created human embryonic kidney cells expressing the human FP prostanoid receptors. These G-coupled receptors are widely found in smooth muscle such as the gastrointestinal tract and in bronchial tissue. As such, the new cell lines are expected to be a useful research tool for investigating receptor activity: they can be used in functional studies of receptor activation and second messenger signaling. They will also provide a sensitive and reliable measure of the potential ...Thu, 21 May 2009 13:17:29 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2334http://arizona.technologypublisher.com/technology/2332Title: Portable Gas Sterilization System Using Disposable Gas Generation Compounds Background: Medical infections remain a major cause of morbidity and mortality in the United States with an estimated healthcare cost of over $60 billion annually. Bacteria and viruses present a huge problem in places such as hospitals and assisted living facilities. Thus, infection control remains a significant problem in both the in-patient and out-patient population. Traditional sterilization methods of medical instruments include: steam (e.g. steam sterilization cannot be used on many plastics), ra...Thu, 21 May 2009 13:17:28 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2332http://arizona.technologypublisher.com/technology/2331Thu, 21 May 2009 13:17:28 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2331http://arizona.technologypublisher.com/technology/2329Thu, 21 May 2009 11:37:35 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2329http://arizona.technologypublisher.com/technology/2327Thu, 21 May 2009 10:16:18 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2327http://arizona.technologypublisher.com/technology/2326Background: The Smith-Waterman algorithm is widely used for local sequence alignment when determining similarities between biomolecule sequences, and is primarily used in DNA and protein sequencing. Smith-Waterman is considered a dynamic algorithm that provides the most accurate results when performing local sequence alignment in difficult-to-determine regions of proteins segments that show a low similarity between distantly related biological sequences resulting from evolutionary "noise." A major issue in current Smith-Waterman implementations, however, is that computational overhead ...Thu, 21 May 2009 10:10:32 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2326http://arizona.technologypublisher.com/technology/2325Background: The Smith-Waterman algorithm is widely used for local sequence alignment when determining similarities between biomolecule sequences, and is primarily used in DNA and protein sequencing. Smith-Waterman is considered a dynamic algorithm that provides the most accurate results when performing local sequence alignment in difficult-to-determine regions of proteins segments that show a low similarity between distantly related biological sequences resulting from evolutionary "noise." A major issue in current Smith-Waterman implementations, however, is that computational overhead ...Thu, 21 May 2009 10:10:31 GMTldemasque@ott.arizona.eduhttp://arizona.technologypublisher.com/technology/2325