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An In Vitro Cellular Bioassay for Assessment and Investigation of Neurotoxicity
This invention provides high speed, low cost, and highly accurate neurotoxicity and developmental neurotoxicity screening methods for a wide variety of compounds.
Background:
Neurotoxicity tests are designed to generate definitive data concerning the adverse effects of a neurotoxic substance on human or animal health or the environment. Neurotoxicity...
Published: 4/3/2023
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Inventor(s): Linda Restifo, Robert Kraft
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays
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A Microfluidic System for Automated Dissociation of Tissue
This invention is an automated system with the ability to dissociate a variety of soft biological tissues, such as those found in the heart or central nervous system, into viable single cells for culture preparation and other various uses. It includes a microfluidic device made from clear, low-cost, biocompatible materials integrated with imaging and...
Published: 2/1/2024
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Inventor(s): Yitshak Zohar, Linda Restifo, Linan Jiang
Keywords(s): automation, drug discovery, flow shear, high throughput screening (HTS), microfluidics, primary neuron culture, tissue dissociation, viability
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation > Microfluidics, Technology Classifications > Research Tools > Screening assays
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Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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NeuronMetrics: Software for Semi-Automated Processing of Cultured-Neuron Images
Thanks for your interest in NeuronMetrics. To download this software please click on the License This Technology link at right, and choose the appropriate use for commercial or academic purposes. The user manual can be downloaded at the bottom link in the right hand column. Once you have completed the license agreement you will be sent a download link...
Published: 4/3/2023
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Inventor(s): Linda Restifo, Alon Efrat, Martha Narro, Robert Kraft, Fan Yang, Carola Wenk
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology, Technology Classifications > Software & Information Technology > Health IT
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CADDMR Technology, Providing a Cell-Based Assay for Drug Discovery for Mental Retardation Disorders
Researchers at the University of Arizona have developed a cell based assay system that can be utilized to develop a drug screen for compounds that normalize the phenotype of mutant neurons. This makes possible the development of a pharmaceutical that, when administered at a crucial stage, can effectively normalize brain development. Additionally, the...
Published: 4/3/2023
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Inventor(s): Linda Restifo, Jacobus Barnard, Robert Kraft
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Screening assays
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