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A Mitochondria-Focused Mouse Model (DRP-1-/- mouse) to Accelerate Gastrointestinal Pathophysiology Research
This invention is a transgenic DRP-1-/- mouse model that will help address the central role of mitochondrial structure-function dynamics in the mammalian intestine. This mouse model harbors an intestine-specific disruption in DRP-1, a key mitochondrial membrane-associated protein, which will be useful in assessing how mitochondrial structure/interaction...
Published: 2/26/2024
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Inventor(s): Virinchipuram Viswanathan, Gayatri Vedantam, Jean Wilson, Jennifer Lising
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models
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A Mitochondria-Focused Mouse Model (OPA-1-/- mouse) to Accelerate Gastrointestinal Pathophysiology Research
The invention is two engineered OPA-1-/- mouse models that will help address the central role of mitochondrial structure-function dynamics in the mammalian intestine – a translationally critical, but extremely underdeveloped, resource. This mouse models harbor an intestine-specific disruption in OPA-1, a key mitochondrial membrane-associated protein,...
Published: 3/18/2024
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Inventor(s): Virinchipuram Viswanathan, Gayatri Vedantam, Jean Wilson, Jennifer Lising
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models
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TROVE: A Translational Resource for Omics-Based Validation of Expression Datasets
Translational Resource for Omics-Based Validation of Expression (TROVE) is a solution-oriented query-able disease database that integrates various -omic data from animals and humans, reflective of the One Health paradigm. The innovation is focused on dataset integration and identification, to immediately provide targeted solutions for identified infection/immunity...
Published: 7/24/2023
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan, Bryan Roxas
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Bioinformatics, Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Vaccines
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A Microbiome Sparing, Organism-Specific Therapy for C. difficile Infection
University of Arizona researchers have developed a water-soluble nanocarrier that is non-toxic to both human tissue and to bacteria. The carrier can complex with oligonucleotides that can bind to bacterial mRNA, preventing translation and inhibiting various bacterial functions.
Background:
The carrier can complex with translation-inhibiting modified...
Published: 4/3/2023
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Inventor(s): David Stewart, Arun Sharma, Gayatri Vedantam
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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A Molecular Diagnostic Tool for Detecting Clostridium difficile Infection, Carriage and Outbreaks
This invention is an extremely sensitive and precise molecular diagnostic tool to accurately identify clostridium difficile strains.
Background:
Clostridium difficile is a healthcare associated infection with significant patient mortality, morbidity, and may result in prolonged hospital stays. It is the leading cause of healthcare-associated infections...
Published: 4/3/2023
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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An Essential and Unique Virulence Molecule in Pathogenic Escherichia Coli
This invention relates to a secreted protein that plays a critical role in mediating virulence of pathogenic E. coli. Utilizing a functionally equivalent mouse pathogen, in both in vitro and in vivo virulence studies, the investigators demonstrated that the premature death of intestinal epithelial cells could be prevented.
Background:
There are...
Published: 4/3/2023
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Inventor(s): Virinchipuram Viswanathan, Gayatri Vedantam
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines
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A Safe, Tolerable, Non-Antibiotic Agent to Prevent or Treat Clostridium Difficile Infection
This invention targets Clostridium Difficile through specific self-destruction modifications. Two synthetic biologic agents based on lactic acid bacteria have been engineered to express C. difficile surface proteins and subsequently adhere to intestinal epithelial cells, mitigating infection of C. difficile.
Background:
Clostridium difficile is an...
Published: 4/3/2023
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Therapeutics
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A Novel Anti-Polysaccharide Antiserum for Detection of Clostridium difficile Bacteria, and Diagnosis of Clostridium difficile Colonization in Complex Clinical Specimens
This technology is an antiserum that is highly specific for Clostridium difficile. This target is available on all clinically relevant strains of Clostridium difficile bacteria.
Background:
Clostridium difficile is a bacteria that causes serious intestinal issues. Each year there are approximately 500,000 cases of Clostridium difficile in the United...
Published: 4/3/2023
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Antibodies
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Probiotic Treatment for Clostridium Difficile Infection
This technology is the administration of probiotic bacterial strains with increased expression of a Clostridium difficile attachment protein. These strains, when administered in animal models challenged with high doses of a virulent C. difficile strain prevented death.
Background
Clostridium difficile is the leading cause of healthcare-associated...
Published: 4/3/2023
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Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan, Michael Mallozzi
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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