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Time Resolved Fluorescence based HTS to Detect Structural Changes in cTnI
This innovation involves the development of a probe that attaches to a specific protein called cardiac troponin I (cTnI), which is involved in muscle contraction of the heart. This probe, created through genetic engineering techniques, is designed to detect changes in cTnI's neighboring protein, cardiac troponin T (cTnT). When there's a change...
Published: 5/13/2024
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Inventor(s): Romi Castillo, Jil Tardiff
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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ARTHUR (Autonomous Remote Telesurgery for Healing in Underserved Regions)
This invention introduces the ability to perform laser-based wound debridement remotely using computer vision and AI. The invention pioneers the remote execution of such procedures, offering a glimpse into a future where medical interventions can be conducted from a distance, potentially revolutionizing healthcare accessibility and efficiency. This...
Published: 4/8/2024
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Inventor(s): Geoffrey Gurtner
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Healthcare Portfolios > Dermatology, Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology > Mobile Application, Technology Classifications > Software & Information Technology > Human Machine Interface
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Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown...
Published: 7/6/2023
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Inventor(s): Rui Chang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
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Myofilament Based Therapeutics for Cardiac Muscle Arrhythmias and Skeletal Muscle Tremors
This invention describes a novel therapeutic approach to treat cardiac muscle arrhythmias and skeletal muscle tremors.
Background:
Cardiac arrhythmias, such as those that cause atrial fibrillation or sudden cardiac death (SCD), are typically viewed as electrical/conduction abnormalities that drive uncoordinated heartbeats and their downstream health...
Published: 4/3/2023
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Inventor(s): Samantha Harris
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences
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Materials Selection Criteria for Electrochemical Sensing Using Organic Electrochemical Transistor (OECT)
This technology is a new method for selecting materials when designing organic electrochemical transistors (OECTs). This method aides the design of OECT-based sensors, enabling optimization for operating power level and sensitivity.
Background:
OECTs are transistors useful in sensing and bioelectronics because they are simple, easy to manufacture,...
Published: 3/12/2024
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Inventor(s): Erin Ratcliff, Songyan Yu
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic
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Design Guideline of Floating Gate Electrolyte-Gated Transistor (FGEGT) Sensors
This technology is a method for designing floating gate electrolyte-gated transistor-based sensors, so that the sensor achieves a maximum sensitivity while maintaining a low operating voltage.
Background:
Electrolyte-gated transistors (EGTs) are a type of transistor particularly useful in biosensors due to their simplicity, sensitivity, low voltage...
Published: 3/12/2024
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Inventor(s): Erin Ratcliff, Songyan Yu
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Biologics
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Enhanced Melanoma Cancer Prevention by Novel Melanotropins
This invention describes a method to stimulate natural production of melanin in the body. This stimulation is provided by a selective gamma-melanocyte stimulating hormone derivative, which incites the increase in melanin in the body. A natural increase confers photo protective properties without the need for UV activation, making it a safe compound.
Background:
Existing...
Published: 3/12/2024
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Inventor(s): Minying Cai, Victor Hruby
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics
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A Peptide Approach to Block eNOS Phosphorylation at T495
This invention is a peptide that blocks eNOS phosphorylation. These peptides are designed to target to block T495 phosporylation site of eNOS. When done, this would prevent the activation of eNOS that leads to superoxide production and overwhelming inflammation. The initial peptide has been shown to reduce NOS derived superoxide and cell barrier loss...
Published: 4/3/2023
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Inventor(s): Stephen Black, Evgeny Zemskov, Qing Lu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Biologics
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Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor
The core portion of the dynorphin protein was identified and modifications were made to that core to allow dynorphin to interact and antagonize a bradykinin receptor which is partially responsible for pain sensations.
Applications:
Since the invention antagonizes a receptor partly responsible for pain, the modified protein can be used as a form...
Published: 4/3/2023
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Inventor(s): Yeon Sun Lee
Keywords(s): ongoing pain
Category(s): Technology Classifications > Life Sciences > Biologics
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Artificial Membranes Incorporating GPCRs for Label-Free, Electrophysiological Measurements of Ligand-GPCR Interactions
This invention consists of an artificial lipid membrane that incorporates G-protein coupled receptors into its structure. It allows direct, label-free measurement of ligand binding and activation of G-protein coupled receptors.
Background:
G-protein coupled receptors are a superfamily of proteins that are very popular drug targets. In 2017, 34%...
Published: 3/12/2024
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Inventor(s): Steven Scott Saavedra, Craig Aspinwall
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Materials > Biomaterials, Technology Classifications > Research Tools > Screening assays
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